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Cited by 30Spaceflight effects on biologyCardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic Control

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Acute and intermediate cardiovascular responses to zero gravity and to fractional gravity levels induced by head-down or head-up tilt

Lathers, Claire M., Diamandis, Peter H., Riddle, Jeanne M., Mukai, Chiaki, Elton, Kay F., Bungo, Michael W., Charles, John B.·1990·The Journal of Clinical Pharmacology
DOI 10.1002/j.1552-4604.1990.tb03614.x
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Abstract

Determination of early cardiovascular responses to simulated gravity levels between 0 and 1 G will add knowledge of cardiovascular responses to space flight. Cardiovascular responses to 6 hours in a -5 degrees head-down bedrest model of weightlessness (0 G) were compared to those in head-up tilts of +10 degrees, +20 degrees, and +42 degrees (1/6, 1/3, and 2/3 G, respectively). Six healthy young adult males experienced the four angles on separate days. Impedance cardiography was used to measure thoracic fluid index, cardiac output, stroke volume, and peak flow. Although much intersubject variation occurred, the mean thoracic fluid content at -5 degrees decreased during the first hour and remained decreased; 6-hour values were similar to +10 degrees and +20 degrees. Heart rate decreased the first 2 hours for all angles, then increased, converging at 3-4 hours, and reached control by hour 6. Stroke volume decreased for the first 3 hours at -5 degrees, +10 degrees, +20 degrees; values at all four angles converged at hour 3 and increased in unison thereafter. Cardiac output and peak aortic flow reflected the angle at start of tilt; values at all angles converged by the second hour, decreased through the third hour, and increased thereafter. Pulse pressure decreased for the first 3 hours for angles -5 degrees, +10 degrees, and +20 degrees, converged at the fourth hour, and returned to control. Peak flow at +42 degrees was constant for the first 3 hours and increased thereafter. Blood pressure decreased for the first 2 hours, although the greatest decrease occurred at -5 degrees and +42 degrees; thereafter, values at all angles increased in unison and converged at the fourth hour. Total peripheral resistance increased during the first hour at -5 degrees and +20 degrees and decreased from hour 3 to hours 5-6 at the +42 degrees angle. Cardiovascular values were related to tilt angle for the first 2 hours of tilt, but after hour 3 values at all four angles began to converge, suggesting that cardiovascular homeostatic mechanisms seek a common adapted state regardless of effective gravity level (tilt angle) up to 2/3 G.

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Crossref · 10.1002/j.1552-4604.1990.tb03614.x

Cites

19 of 19 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 9

  1. Georgiyevskiy VS, 1971, Orthostatic stability in an experiment with 30‐day hypodynamia, Kosm Biol Med, 7, 61
  2. Voskresenskiy AD, 1972, Organization of the experiments and overall conditions of the subjects, Kosm Biol Med, 6, 28
  3. Blomqvist CG, 1983, Cardiovascular responses to head‐down tilt in young and middle‐aged men, Physiologist, 26, S81
  4. Johnson RL, 1977, Biomedical results from Skylab., 284
  5. Hyatt KL, 1971, Hypogravic and Hemodynamic Environments., 187
  6. Billman GE, 1981, Horizontal body casting and baroreceptor sensitivity: the role of central blood volume shifts in the rhesus monkey, Aerospace Med Assn Reprints, 52, 82
  7. Thompson FJ, 1983, Venous afferent elicited skeletal muscle pumping: a new orthostatic venopressor mechanism, Physiologist, 26, Suppl 74
  8. Norsk P, 1981, Cardiovascular effects of clonidine during 20 hours head‐down tilt (–5°), Physiologist, 24, S91
  9. Schmid PG, 1971, Hypogravic and Hemodynamic Environments., 211

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Metadata

Authors
Lathers, C. M., Diamandis, P. H., Riddle, J. M., Mukai, C., Elton, K. F., Bungo, M. W., & Charles, J. B.
Affiliations
  • Universities Space Research Association (US)
  • Harvard University (US)
  • Johnson Space Center (US)
ORCID
Charles, John B.
Venue
The Journal of Clinical Pharmacology
Publisher
Wiley
Published
1990-06
Volume
30
Issue
6
Pages
494-523
ISSN
  • 0021-9754 (ISSN-L)
  • 0091-2700
  • 1552-4604
DOI
10.1002/j.1552-4604.1990.tb03614.x
OpenAlex
W2046132989
Cited by
30
References
19
Citations by year
2023: 2 · 2019: 2 · 2017: 2 · 2015: 1 · 2014: 1 · 2012: 1
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8316 d)
Locations
  • The Journal of Clinical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
microgravity, head-down tilt, head-up tilt, cardiovascular response, spaceflight, bed rest, thoracic fluid content, cardiac output, stroke volume, heart rate, blood pressure, systemic vascular resistance, pulse pressure, aortic blood flow, cardiovascular homeostasis
MeSH terms
Bed Rest, Blood Pressure, Cardiac Output, Cardiography, Impedance, Echocardiography, Heart Rate, Hemodynamics, Humans, Male, Posture, Space Flight, Stroke Volume, Vascular Resistance, Weightlessness

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