Changes in Total Body Water During Spaceflight
Abstract
This experiment represents the first time that it has been possible to measure a body fluid compartment by direct means during spaceflight. Based on the results observed in the five crewmen in this study, it is concluded that TBW decreases by 3.4% after 1 to 3 days of exposure to microgravity in the Space Shuttle. Some individuals appear to undergo this decrease within 24 hours. This effect may be enhanced by decreased water intake due to nausea associated with SMS.
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When an astronaut is in orbit, a fluid shift from the intracellular to the extracellular compartment occurs due to increased permeability of capillary membranes.
“When an astronaut is in orbit, a fluid shift from the intracellular to the extracellular compartment occurs due to increased permeability of capillary membranes110,111.”
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References 10 · Cited by 77
- Authors
- Leach, C. S., Inners, L. D., & Charles, J. B.
- Affiliations
- National Aeronautics and Space Administration (US)
- Corresponding author
- Leach, Carolyn S.
- ORCID
- Charles, John B.
- Venue
- The Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1991-10
- Volume
- 31
- Issue
- 10
- Pages
- 1001-1006
- ISSN
- 0021-9754 (ISSN-L)
- 0091-2700
- 1552-4604
- OpenAlex
- W2092718499
- Cited by
- 77
- References
- 10
- Citations by year
- 2025: 3 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 5 · 2013: 1 · 2012: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Physical Sciences › Engineering › Aerospace Engineering › Space Exploration and Technology
- Keywords
- total body water, spaceflight, microgravity, Space Shuttle, body fluid compartments, space motion sickness, nausea, water intake
- MeSH terms
- Adult, Analysis of Variance, Body Water, Body Weight, Humans, Male, Oxygen Isotopes, Saliva, Space Flight
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