CoChat
Sign Up
Cited by 165Poisoning and overdose treatmentsCassava research and cyanideHistorical and Scientific Studies

The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning

Baskin, Steven I., Horowitz, Arthur M., Nealley, Eric W.·1992·The Journal of Clinical Pharmacology
DOI 10.1002/j.1552-4604.1992.tb03849.x
Open this paper in CoChat — free account

Abstract

The combination of sodium thiosulfate and sodium nitrite has been used in the United States since the 1930s as the primary antidote for cyanide intoxication. Although this combination was shown to exhibit much greater efficacy than either ingredient alone, the two compounds could not be used prophylactically because each exhibits a number of side effects. This review discusses the pharmacodynamics, pharmacokinetics, and toxicology of the individual agents, and their combination.

Integrity signals

Registry

Crossref · 10.1002/j.1552-4604.1992.tb03849.x

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

The citation lists haven’t been fetched yet

References 78 · Cited by 165

Authors
Baskin, S. I., Horowitz, A. M., & Nealley, E. W.
Affiliations
United States Army (US)
Corresponding author
Baskin, Steven I.
Venue
The Journal of Clinical Pharmacology
Publisher
Wiley
Published
1992-04
Volume
32
Issue
4
Pages
368-375
ISSN
  • 0021-9754 (ISSN-L)
  • 0091-2700
  • 1552-4604
DOI
10.1002/j.1552-4604.1992.tb03849.x
OpenAlex
W2002565670
Cited by
165
References
78
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 11 · 2014: 4 · 2013: 8 · 2012: 9
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7646 d)
Locations
  • The Journal of Clinical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Cassava research and cyanide
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Historical and Scientific Studies
Keywords
cyanide poisoning, sodium nitrite, sodium thiosulfate, antidotes, pharmacodynamics, pharmacokinetics, toxicology, adverse effects, prophylaxis
MeSH terms
Animals, Antidotes, Biological Availability, Cyanides, Drug Therapy, Combination, Humans, Poisoning, Sodium Nitrite, Thiosulfates

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review