The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Update: Clinically Significant Cytochrome P‐450 Drug Interactions
Open accessAbstract
Recent technologies have resulted in an explosion of information concerning the cytochrome P‐450 isoenzymes and increased awareness of life‐threatening interactions' with such commonly prescribed drugs as cisapride and some antihistamines. Knowledge of the substrates, inhibitors, and inducers of these enzymes assists in predicting clinically significant drug interactions. In addition to inhibition and induction, microsomal drug metabolism is affected by genetic polymorphisms, age, nutrition, hepatic disease, and endogenous chemicals. Of the more than 30 human isoenzymes identified to date, the major ones responsible for drug metabolism include CYP3A4, CYP2D6, CYP1A2, and the CYP2C subfamily.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Terfenadine-Ketoconazole Interaction: Pharmacokinetic and Electrocardiographic Consequences
Honig, P. K. (1993) · JAMA · doi:10.1001/jama.1993.03500120051025 · Cited by 664
Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid
Neuvonen, P. J., & Jalava, K.-M. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90167-8 · Cited by 238
Adverse Effects of Phenobarbital on Corticosteroid Metabolism in Patients with Bronchial Asthma
Brooks, S. M., Werk, E. E., Ackerman, S. J., Sullivan, I., & Thrasher, K. (1972) · New England Journal of Medicine · doi:10.1056/nejm197205252862103 · Cited by 179
Rhabdomyolysis from the Coadministration of Lovastatin and the Antifungal Agent Itraconazole
Lees, R. S., & Lees, A. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509073331015 · Cited by 136
Cited by
Jacobi, J., Fraser, G. L., Coursin, D. B., Riker, R. R., Fontaine, D., Wittbrodt, E. T., Chalfin, D. B., Masica, M. F., Bjerke, H. S., Coplin, W. M., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200201000-00020 · Cited by 1,895
The PPARs: From Orphan Receptors to Drug Discovery
Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990554g · Cited by 1,816
(2007) · PubMed · Cited by 953
Bauer, M., Pfennig, A., Severus, E., Whybrow, P. C., Angst, J., Möller, H.-J., & Šon behalf of the Task Force on Unipolar Depressive Disorders (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.804195 · Cited by 632
Cytochrome P450 3A: Ontogeny and Drug Disposition
de Wildt, S. N., Kearns, G. L., Leeder, J. S., & van den Anker, J. N. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199937060-00004 · Cited by 586
Metadata
- Authors
- Michalets, E. L.
- Venue
- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
- Publisher
- Wiley
- Published
- 1998-01-02
- Volume
- 18
- Issue
- 1
- Pages
- 84-112
- ISSN
- 0277-0008 (ISSN-L)
- 1875-9114
- OpenAlex
- W1926862327
- Cited by
- 597
- References
- 4
- FWCI
- 52.64
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Update: Clinically Significant Cytochrome P‐450 Drug Interactions. https://app.cochat.ai/papers/10.1002/j.1875-9114.1998.tb03830.x
- The paper
- Michalets, E. L. (1998). Update: Clinically Significant Cytochrome P‐450 Drug Interactions. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. https://doi.org/10.1002/j.1875-9114.1998.tb03830.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
