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Biotransformation of dimethylarsinic acid in mouse, hamster and man
Abstract
The metabolism of dimethylarsinic acid (DMA) a common pesticide and the main metabolite of inorganic arsenic in mammals, has been studied in mice, hamsters and man. Mice and hamsters were administered a single dose of 74 As‐DMA (40 mg As/kg body weight) orally, while a human subject ingested DMA corresponding to 0.1 mg As/kg body weight. Ion exchange chromatography, paper electrophoresis, thin layer chromatography as well as arsine generation—gas chromatography combined with atomic absorption spectrophotometry or mass spectrometry were used to characterize the arsenic metabolites in urine and feces collected over 48 hours after treatment. In mice and hamsters 3.5% and 6.4% of the dose, respectively, were excreted in urine in the form of trimethylarsine oxide (TMAO). No TMAO was found in feces. A DMA‐complex was detected in urine and feces. It amounted to about 13% of the dose in mice and 15% in hamsters. About 80–85% of the dose was eliminated in urine and feces in the form of unmetabolized DMA. No demethylation of DMA to inorganic arsenic was observed. In man, about 4% of the dose was excreted in urine as TMAO and about 80% as DMA.
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Citations
Cites
Challenger, F. (1945) · Chemical Reviews · doi:10.1021/cr60115a003 · Cited by 584
Cited by
Arsenic Exposure and Toxicology: A Historical Perspective
Hughes, M. F., Beck, B. D., Chen, Y., Lewis, A. S., & Thomas, D. J. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr184 · Cited by 1,312
Mechanisms of arsenic biotransformation
Vahter, M. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00285-8 · Cited by 757
Self-citationMechanism of arsenic carcinogenesis: an integrated approach
Rossman, T. G. (2003) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2003.07.009 · Cited by 559
Methylation of Inorganic Arsenic in Different Mammalian Species and Population Groups
Vahter, M. (1999) · Science Progress · doi:10.1177/003685049908200104 · Cited by 370
Self-citationMethylated Arsenic Species in Rice: Geographical Variation, Origin, and Uptake Mechanisms
Zhao, F.-J., Zhu, Y.-G., & Meharg, A. A. (2013) · Environmental Science & Technology · doi:10.1021/es304295n · Cited by 353
Metadata
- Authors
- Marafante, E., Vahter, M., Norin, H., Envall, J., Sandström, M., Christakopoulos, A., & Ryhage, R.
- Venue
- Journal of Applied Toxicology
- Publisher
- Wiley
- Published
- 1987-04
- Volume
- 7
- Issue
- 2
- Pages
- 111-117
- ISSN
- 0260-437X (ISSN-L)
- 1099-1263
- OpenAlex
- W1995335028
- Cited by
- 158
- References
- 1
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marafante, E., Vahter, M., Norin, H., Envall, J., Sandström, M., Christakopoulos, A., & Ryhage, R. (1987). Biotransformation of dimethylarsinic acid in mouse, hamster and man. Journal of Applied Toxicology. https://doi.org/10.1002/jat.2550070207
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
