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Cited by 268Optical Polarization and EllipsometryOptical Imaging and Spectroscopy TechniquesSpectroscopy Techniques in Biomedical and Chemical Research

Mueller polarimetric imaging for surgical and diagnostic applications: a review

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Qi, Ji, Elson, Daniel S.·2017·Journal of Biophotonics
DOI 10.1002/jbio.201600152
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Abstract

Polarization is a fundamental property of light and a powerful sensing tool that has been applied to many areas. A Mueller matrix is a complete mathematical description of the polarization characteristics of objects that interact with light, and is known as a transfer function of Stokes vectors which characterise the state of polarization of light. Mueller polarimetric imaging measures Mueller matrices over a field of view and thus allows for visualising the polarization characteristics of the objects. It has emerged as a promising technique in recent years for tissue imaging, improving image contrast and providing a unique perspective to reveal additional information that cannot be resolved by other optical imaging modalities. This review introduces the basis of the Stokes-Mueller formulism, interpretation methods of Mueller matrices into fundamental polarization properties, polarization properties of biological tissues, and considerations in the construction of Mueller polarimetric imaging devices for surgical and diagnostic applications, including primary configurations, optimization procedures, calibration methods as well as the instrument polarization properties of several widely-used biomedical optical devices. The paper also reviews recent progress in Mueller polarimetric endoscopes and fibre Mueller polarimeters, followed by the future outlook in applying the technique to surgery and diagnostics. Tissue polarization properties convey morphological, micro-structural and compositional information of tissue with great potential for label free characterization of tissue pathological changes. Recent progress in tissue polarimetric imaging and polarization resolved endoscopy paved the way for translation of polarimetric imaging to surgery and tissue diagnosis.

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  • Some medical optical imaging techniques use polarized light including polarization-sensitive OCT, polarized light elastic scattering spectroscopy, and cross-polarized light imaging.

    “some medical optical imaging techniques use polarized light including polarization-sensitive OCT, polarized light elastic scattering spectroscopy, and cross-polarized light imaging.149–151”

    From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [151]

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Authors
Qi, J., & Elson, D. S.
Affiliations
Imperial College London (GB)
Corresponding author
  • Qi, Ji
  • Elson, Daniel S.
ORCID
Venue
Journal of Biophotonics
Publisher
Wiley
Published
2017-05-02
Volume
10
Issue
8
Pages
950-982
ISSN
1864-063X (ISSN-L)
DOI
10.1002/jbio.201600152
OpenAlex
W2592774311
Cited by
268
References
184
Citations by year
2026: 26 · 2025: 33 · 2024: 31 · 2023: 31 · 2022: 45 · 2021: 33 · 2020: 25 · 2019: 24 · 2018: 10 · 2017: 5 · 2014: 1
FWCI
1.41
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biophotonics (publishedVersion)
  • PubMed (publishedVersion)
  • Spiral (Imperial College London) (submittedVersion)
Funders
  • European Research Council (242991)
  • National Institute of Health Research i4i award (II-LB-0214-20009)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Optical Polarization and Ellipsometry
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Keywords
Mueller matrix, Stokes vector, surgical imaging, instrument calibration
MeSH terms
Humans, Light, Spectrum Analysis, Endoscopes, Optical Devices, Optical Imaging

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