A study of the interface between a fibrous polyurethane arterial prosthesis and natural tissue
Abstract
Fibrous polyurethane samples were implanted in subcutaneous tissue, muscle, and as an arterial prosthesis for periods up to six months. The interface between the polymer and living tissue was studied using optical, scanning, and transmission electron microscopy. A good correlation was found between the micromorphology of the polymer–tissue interface observed in three experimental methods used. Ingrowth of tissue occurs by cell penetration into the fibrous network of the polymer implant and eventual encapsulation by connective tissue. Full details of the distribution of collagen and the cell components around the individual polymer fibers and the structure of the connective tissue are given.
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These earlier studies used materials with broad pore-size distributions (only average pore size was reported), making conclusions about the effects of pore size difficult.
“These earlier studies used materials with broad pore-size distributions (only average pore size was reported), making conclusions about the effects of pore size difficult.”
From Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010) · cites this paper as [32]
Pore size effects observed here relate to previous studies in which 10- to 45-μm pores filled with fibrohistiocytic tissue, whereas pores >45 μm filled with organized fibrous tissue.
“Pore size effects observed here relate to previous studies in which 10- to 45-μm pores filled with fibrohistiocytic tissue, whereas pores >45 μm filled with organized fibrous tissue (31, 32).”
From Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010) · cites this paper as [32]
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References 13 · Cited by 17
- Authors
- Beahan, P., & Hull, D.
- Affiliations
- University of Liverpool (GB)
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1982-11
- Volume
- 16
- Issue
- 6
- Pages
- 827-838
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W1990635510
- Cited by
- 17
- References
- 13
- Citations by year
- 2012: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- tissue ingrowth, collagen distribution, cell penetration, subcutaneous implantation, biocompatibility
- MeSH terms
- Animals, Aorta, Blood Vessel Prosthesis, Microscopy, Electron, Scanning, Polyurethanes, Swine, Swine, Miniature
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