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Osteoblast responses to orthopedic implant materials in vitro
Abstract
Responses of neonatal rat calvarial osteoblasts to a variety of orthopedic implant materials were examined in vitro. Attachment, proliferation, and collagen synthesis of a well‐characterized line of osteoblasts with 316L stainless steel, Ti‐6Al‐4V, CoCR‐Mo, PMMA, hydroxyapatite, borosilicate glass, and tissue culture polystyrene were studied. Cell adhesion and growth were similar on nonapatitic materials. In contrast, attachment and growth of osteoblasts were significantly lower and slower, respectively, on hydroxyapatite. Collagen synthesis per cell and relative collagen synthesis, however, were comparable on all the materials tested.
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Cited by
Hierarchically biomimetic bone scaffold materials: nano‐HA/collagen/PLA composite
Liao, S. S., Cui, F. Z., Zhang, W., & Feng, Q. L. (2004) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.20035 · Cited by 487
Hollander, D. A., von Walter, M., Wirtz, T., Sellei, R., Schmidt-Rohlfing, B., Paar, O., & Erli, H.-J. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.07.041 · Cited by 482
Bone tissue engineering with premineralized silk scaffolds
Kim, H. J., Kim, U.-J., Kim, H. S., Li, C., Wada, M., Leisk, G. G., & Kaplan, D. L. (2008) · Bone · doi:10.1016/j.bone.2008.02.007 · Cited by 293
Cell culture methods for testing Biocompatibility
Pizzoferrato, A., Ciapetti, G., Stea, S., Cenni, E., Arciola, C. R., Granchi, D., & Lucia (1994) · Clinical Materials · doi:10.1016/0267-6605(94)90081-7 · Cited by 207
Metadata
- Authors
- Puleo, D. A., Holleran, L. A., Doremus, R. H., & Bizios, R.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1991-06
- Volume
- 25
- Issue
- 6
- Pages
- 711-723
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2059906854
- Cited by
- 330
- References
- 0
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Osteoblast responses to orthopedic implant materials in vitro. https://app.cochat.ai/papers/10.1002/jbm.820250603
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- Puleo, D. A., Holleran, L. A., Doremus, R. H., & Bizios, R. (1991). Osteoblast responses to orthopedic implant materials in vitro. Journal of Biomedical Materials Research. https://doi.org/10.1002/jbm.820250603
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