Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization
Open accessAbstract
Mineralized hydrogels are increasingly gaining attention as biomaterials for bone regeneration. The most common mineralization strategy has been addition of preformed inorganic particles during hydrogel formation. This maintains injectability. One common form of bone cement is formed by mixing particles of the highly reactive calcium phosphate alpha‐tricalcium phosphate (α‐TCP) with water to form hydroxyapatite (HA). The calcium ions released during this reaction can be exploited to crosslink anionic, calcium‐binding polymers such as the polysaccharide gellan gum (GG) to induce hydrogel formation. In this study, three different amounts of α‐TCP particles were added to GG polymer solution to generate novel, injectable hydrogel‐inorganic composites. Distribution of the inorganic phase in the hydrogel was studied by high resolution microcomputer tomography (µCT). Gelation occurred within 30 min. α‐TCP converted to HA. µCT revealed inhomogeneous distribution of the inorganic phase in the composites. These results demonstrate the potential of the composites as alternatives to traditional α‐TCP bone cement and pave the way for incorporation of biologically active substances and in vitro and in vivo testing. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 822–828, 2018.
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XG side chains are made up of D-mannose and D-glucuronic acid in a 2:1 ratio, and its backbone is the same as that of cellulose.
“Its side chains are made up of D-mannose and D-glucuronic acid in a 2:1 ratio, and its backbone is the same as that of cellulose [66].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [66]
The Introduction discusses gellan gum hydrogels and their crosslinking with calcium, but does not describe XG’s molecular structure. Searches for D-mannose, D-glucuronic acid, the 2:1 ratio, and a cellulose-like backbone found no passage addressing the claim. (LLM, conf=0.76)
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Research works printed but not linked: 24
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Douglas, T. E. L., Schietse, J., Zima, A., Gorodzha, S., Parakhonskiy, B. V., KhaleNkow, D., Shkarin, R., Ivanova, A., Baumbach, T., Weinhardt, V., Stevens, C. V., Vanhoorne, V., Vervaet, C., Balcaen, L., Vanhaecke, F., Slośarczyk, A., Surmeneva, M. A., Surmenev, R. A., & Skirtach, A. G.
- Affiliations
- Ghent University (BE)
- AGH University of Krakow (PL)
- Tomsk Polytechnic University (RU)
- Saratov State University (RU)
- Karlsruhe Institute of Technology (DE)
- A.V. Shubnikov Institute of Crystallography (RU)
- Engineering Department Lancaster University Lancaster United Kingdom
- Department of Experimental Physics National Research Tomsk Polytechnic University Tomsk Russia
- Department of Molecular Biotechnology Ghent University Ghent Belgium
- Corresponding author
- Douglas, Timothy E. L.
- ORCID
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2017-11-29
- Volume
- 106
- Issue
- 3
- Pages
- 822-828
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- OpenAlex
- W2785504458
- Cited by
- 47
- References
- 0
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 6
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.lancs.ac.uk
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- Lancaster EPrints (Lancaster University) (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- FWO
- BOF
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
- Keywords
- injectable hydrogel, alpha-tricalcium phosphate, gellan gum, hydroxyapatite, bone regeneration, bone cement, calcium phosphate mineralization, gelation
- MeSH terms
- Bone Regeneration, Calcium Phosphates, Injections, Microcomputers, Minerals, Particle Size, Tomography, Tomography, X-Ray Computed, Hydrogels, Chemical Phenomena
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