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Cited by 38Laser Material Processing TechniquesPolymer Surface Interaction StudiesCoronary Interventions and Diagnostics

Surface patterning of a novel PEG‐functionalized poly‐l‐lactide polymer to improve its biocompatibility: Applications to bioresorbable vascular stents

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Pacharra, Sandra, Ortiz, Rocio, McMahon, Sean, Wang, Wenxin, Viebahn, Richard, Salber, Jochen, Quintana, Iban·2019·Journal of Biomedical Materials Research Part B: Applied Biomaterials
DOI 10.1002/jbm.b.34155PMC PMC6585964
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Abstract

Today, research in the field of bioresorbable vascular stents (BVS) not only focusses on a new material being nontoxic but also tries to enhance its biocompatibility in terms of endothelialization potential and hemocompatibility. To this end, we used picosecond laser ablation technology as a single‐step and contactless method for surface microstructuring of a bioresorbable polymer which can be utilized in stent manufacture. The method works on all materials via fast material removal, can be easily adapted for micropatterning of tubular or more complex sample shapes and scaled up by means of micropatterning of metal molds for manufacturing. Here, picosecond laser ablation was applied to a bioresorbable, biologically inactive and polyethylene glycol‐modified poly‐L‐lactide polymer (PEGylated PLLA) to generate parallel microgrooves with varying geometries. The different patterns were thoroughly evaluated by a series of cyto‐ and hemocompatibility tests revealing that all surfaces were non‐toxic and non‐hemolytic. More importantly, patterns with 20 to 25 µm wide and 6 to 7 µm deep grooves significantly enhanced endothelial cell adhesion in comparison to samples with smaller grooves. Here, human cardiac microvascular endothelial cells were found to align along the groove direction, which is thought to encourage endothelialization of intraluminal surfaces of BVS. © 2018 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 00B: 000–000, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 624–634, 2019.

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  • PEG functionalised PLLA with low PEG content (0.1-1.5 wt%) shows increased water absorption and degradation rate due to the presence of PEG.

    “Despite the low PEG content, similar results are seen, with increased water absorption and degradation rate resulting from the presence (but not length) of PEG”

    From Tuning structural relaxations, mechanical properties, and degradation timescale of PLLA during hydrolytic degradation by blending with PLCL-PEG (2019) · cites this paper as [35]

    The Discussion (page not provided) says PEG improves PLLA’s hydrophilicity and that incorporating PEG tunes its degradation rate. It does not report increased water absorption, establish that degradation is faster, give a PEG content of 0.1–1.5 wt%, or compare PEG lengths. (LLM, conf=0.82)

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Authors
Pacharra, S., Ortiz, R., McMahon, S., Wang, W., Viebahn, R., Salber, J., & Quintana, I.
Affiliations
  • Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
  • Ultraprecision Processes Unit, IK4‐TEKNIKER Technological Research Center Eibar Gipuzkoa Spain
  • Vornia Ltd, Laboratory A, Synergy Centre, Tallaght Dublin Ireland
  • University College Dublin (IE)
  • Tekniker (ES)
Corresponding author
Salber, Jochen
ORCID
Venue
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Publisher
Wiley
Published
2018-08-09
Volume
107
Issue
3
Pages
624-634
ISSN
  • 1552-4973 (ISSN-L)
  • 1552-4981
DOI
10.1002/jbm.b.34155
PMC
PMC6585964
OpenAlex
W2885679047
Cited by
38
References
0
Citations by year
2026: 1 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 9 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 1
FWCI
2.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Irish Research Council (EBPPG/2014/70)
Topics
  • Physical Sciences › Engineering › Computational Mechanics › Laser Material Processing Techniques
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
Keywords
surface microstructuring, picosecond laser ablation, endothelialization, endothelial cell alignment, hemocompatibility, biocompatibility, microgrooves, cardiac microvascular endothelial cells, hemolysis
MeSH terms
Animals, Blood Vessel Prosthesis, Cell Line, Humans, Materials Testing, Polyesters, Polyethylene Glycols, Surface Properties, Stents, Endothelial Cells, Mice

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