The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Fabrication and evaluation of bacterial nanocellulose/poly (acrylic acid)/graphene oxide composite hydrogel: characterizations and biocompatibility studies for wound dressing
Abstract
Graphene oxide (GO) is a potential material for wound dressing due to its excellent biocompatibility and mechanical properties. This study evaluated the effects of GO concentration on the synthesis of bacterial nanocellulose (BNC)-grafted poly(acrylic acid) (AA)-graphene oxide (BNC/P(AA)/GO) composite hydrogel and its potential as wound dressing. Hydrogels were successfully synthesized via electron-beam irradiation. The hydrogels were characterized by their mechanical properties, bioadhesiveness, water vapor transmission rates (WVTRs), water retention abilities, water absorptivity, and biocompatibility. Fourier transform infrared analysis showed the successful incorporation of GO into hydrogel. Thickness, gel fraction determination and morphological study revealed that increased GO concentration in hydrogels leads to reduced crosslink density and larger pore size, resulting in increased WVTR. Thus, highest swelling ratio was found in hydrogel with higher amount of GO (0.09 wt %). The mechanical properties of the composite hydrogel were maintained, while its hardness and bioadhesion were reduced with higher GO concentration in the hydrogel, affirming the durable and easy removable properties of a wound dressing. Human dermal fibroblast cell attachment and proliferation studies showed that biocompatibility of hydrogel was improved with the inclusion of GO in the hydrogel. Therefore, BNC/P(AA)/GO composite hydrogel has a potential application as perdurable wound dressing. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2140-2151, 2019.
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“On the other hand, more MBA concentration decreased the porosity by increasing the cross-linking density resulting in reduced pore size (Babaei et al., 2019;Chen et al., 2019).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Chen et al., 2019
In the citing paper
“On the other hand, more MBA concentration decreased the porosity by increasing the cross-linking density resulting in reduced pore size (Babaei et al., 2019;Chen et al., 2019).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Chen et al., 2019
Citations
Cites
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Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene Oxide
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Water Radiolysis: Influence of Oxide Surfaces on H2 Production under Ionizing Radiation
Le Caër, S. (2011) · Water · doi:10.3390/w3010235 · Cited by 699
Bacterial cellulose and bacterial cellulose–chitosan membranes for wound dressing applications
Lin, W.-C., Lien, C.-C., Yeh, H.-J., Yu, C.-M., & Hsu, S.-H. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.01.076 · Cited by 686
Overview of Bacterial Cellulose Production and Application
Esa, F., Tasirin, S. M., & Rahman, N. A. (2014) · Agriculture and Agricultural Science Procedia · doi:10.1016/j.aaspro.2014.11.017 · Cited by 503
Stretchable and Self-Healing Graphene Oxide–Polymer Composite Hydrogels: A Dual-Network Design
Cong, H., Wang, P., & Yu, S. (2013) · Chemistry of Materials · doi:10.1021/cm401919c · Cited by 343
First Nitroxide-Mediated Controlled Free-Radical Polymerization of Acrylic Acid
Couvreur, L., Lefay, C., Belleney, J., Charleux, B., Guerret, O., & Magnet, S. (2003) · Macromolecules · doi:10.1021/ma035043p · Cited by 334
Huang, Y., Zeng, M., Ren, J., Wang, J., Fan, L., & Xu, Q. (2012) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2012.03.031 · Cited by 327
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Cited by
Noureen, S., Noreen, S., Ghumman, S. A., Abdelrahman, E. A., Batool, F., Aslam, A., Mehdi, M., Shirinfar, B., & Ahmed, N. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106555 · Cited by 28
“On the other hand, more MBA concentration decreased the porosity by increasing the cross-linking density resulting in reduced pore size (Babaei et al., 2019; Chen et al., 2019).”
BackgroundpH-sensitive hydrogel from Colocasia esculenta mucilage for controlled tramadol release
Noureen, S., Noreen, S., Ghumman, S. A., Batool, F., & Ahmed, N. (2025) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2025.103973 · Cited by 2
Metadata
- Authors
- Chen, X. Y., Low, H. R., Loi, X. Y., Merel, L., & Mohd Cairul Iqbal, M. A.
- Affiliations
- National University of Malaysia (MY)
- Université Clermont Auvergne (FR)
- Faculty of Pharmacy Universiti Kebangsaan Malaysia (UKM), Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur Malaysia
- ORCID
- Chen, Xiang Yi
- Venue
- Journal of Biomedical Materials Research Part B Applied Biomaterials
- Publisher
- Wiley
- Published
- 2019-02-13
- Volume
- 107
- Issue
- 6
- Pages
- 2140-2151
- ISSN
- 1552-4973 (ISSN-L)
- 1552-4981
- OpenAlex
- W2911458587
- Cited by
- 53
- References
- 35
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 7 · 2021: 7 · 2020: 8
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universiti Kebangsaan Malaysia
- Topics
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- bacterial nanocellulose, poly(acrylic acid), graphene oxide, composite hydrogels, wound dressings, electron beam crosslinking, water vapor transmission rate, swelling ratio, mechanical properties, bioadhesion, biocompatibility, dermal fibroblast proliferation, crosslink density, pore size
- MeSH terms
- Acrylic Resins, Animals, Bacteria, Bandages, Cell Adhesion, Cellulose, Fibroblasts, Graphite, Humans, Materials Testing, Hydrogels, Cell Proliferation, Rats, Nanocomposites
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