The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness
Open accessAbstract
The need, safety, and effectiveness of vitamin D supplementation during pregnancy remain controversial. In this randomized, controlled trial, women with a singleton pregnancy at 12 to 16 weeks' gestation received 400, 2000, or 4000 IU of vitamin D3 per day until delivery. The primary outcome was maternal/neonatal circulating 25-hydroxyvitamin D [25(OH)D] concentration at delivery, with secondary outcomes of a 25(OH)D concentration of 80 nmol/L or greater achieved and the 25(OH)D concentration required to achieve maximal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production. Of the 494 women enrolled, 350 women continued until delivery: Mean 25(OH)D concentrations by group at delivery and 1 month before delivery were significantly different (p < 0.0001), and the percent who achieved sufficiency was significantly different by group, greatest in 4000-IU group (p < 0.0001). The relative risk (RR) for achieving a concentration of 80 nmol/L or greater within 1 month of delivery was significantly different between the 2000- and the 400-IU groups (RR = 1.52, 95% CI 1.24–1.86), the 4000- and the 400-IU groups (RR = 1.60, 95% CI 1.32–1.95) but not between the 4000- and. 2000-IU groups (RR = 1.06, 95% CI 0.93–1.19). Circulating 25(OH)D had a direct influence on circulating 1,25(OH)2D3 concentrations throughout pregnancy (p < 0.0001), with maximal production of 1,25(OH)2D3 in all strata in the 4000-IU group. There were no differences between groups on any safety measure. Not a single adverse event was attributed to vitamin D supplementation or circulating 25(OH)D levels. It is concluded that vitamin D supplementation of 4000 IU/d for pregnant women is safe and most effective in achieving sufficiency in all women and their neonates regardless of race, whereas the current estimated average requirement is comparatively ineffective at achieving adequate circulating 25(OH)D concentrations, especially in African Americans. © 2011 American Society for Bone and Mineral Research
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Cites
2 retracted
Vitamin D supplementation in pregnancy
Mahomed, K., & Gülmezoglu, A. M. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000228.pub2 · Cited by 91
RetractedVitamin D supplementation in pregnancy
Mahomed, K., & Gülmezoglu, A. M. (1999) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000228 · Cited by 44
RetractedHolick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., & Weaver, C. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0385 · Cited by 10,538
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Self-citationVitamin D deficiency and risk of cardiovascular disease
Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K., Benjamin, E. J., D’Agostino, R. B., Wolf, M., & Vasan, R. S. (2008) · Circulation · doi:10.1161/circulationaha.107.706127 · Cited by 1,846
Mittal, M., Kumar, A., Ramji, S., Narula, S., & Thirupuram, S. (1990) · PubMed · Cited by 1,764
Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents
Wagner, C. L., Greer, F. R., & and the Section on Breastfeeding and Committee on Nutrition (2008) · Pediatrics · doi:10.1542/peds.2008-1862 · Cited by 1,613
Self-citationDistribution of the vitamin D receptor and 1α-hydroxylase in human brain
Eyles, D. W., Smith, S., Kinobe, R., Hewison, M., & McGrath, J. J. (2005) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2004.08.006 · Cited by 1,444
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
Heaney, R. P., Davies, K. M., Chen, T. C., Holick, M. F., & Barger-Lux, M. J. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.204 · Cited by 1,396
Hollis, B. W. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.2.317 · Cited by 1,162
Self-citation
Cited by
The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention
Holick, M. F. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9424-1 · Cited by 1,511
Sunlight and Vitamin D: A global perspective for health
Wacker, M., & Holick, M. F. (2013) · Dermato-Endocrinology · doi:10.4161/derm.24494 · Cited by 1,156
Pludowski, P., Holick, M. F., Pilz, S., Wagner, C. L., Hollis, B. W., Grant, W. B., Shoenfeld, Y., Lerchbaum, E., Llewellyn, D. J., Kienreich, K., et al. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.02.004 · Cited by 836
Self-citationVitamin D supplementation for women during pregnancy
De-Regil, L. M., Palacios, C., Lombardo, L. K., & Peña-Rosas, J. P. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008873.pub3 · Cited by 744
Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery
Kovacs, C. S. (2016) · Physiological Reviews · doi:10.1152/physrev.00027.2015 · Cited by 544
Metadata
- Authors
- Hollis, B. W., Johnson, D., Hulsey, T. C., Ebeling, M., & Wagner, C. L.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-27
- Volume
- 26
- Issue
- 10
- Pages
- 2341-2357
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2132096646
- Cited by
- 846
- References
- 89
- FWCI
- 45.41
- Type
- journal article
- Language
- en
- Open access
- green
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