The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Zinc is a potent inhibitor of osteoclastic bone resorption in vitro
Abstract
It is well established that zinc, an essential trace element, plays an important role in growth and stimulates bone formation. However, the effects of zinc on bone resorption have received little attention. We studied its effects on isolated rat osteoclasts. Unexpectedly, osteoclasts were exquisitely sensitive to zinc, with a significant decrease in bone resorption occurring at concentrations as low as 10−14 M. This effect was specific for zinc and was not observed with the other transitional or alkaline metals studied. There was no evidence of toxicity at concentrations up to 10−4 M. Zinc also completely abolished the stimulatory effect of parathyroid hormone. Zinc is therefore a highly potent and selective inhibitor of osteoclastic bone resorption in vitro. The mode of action remains to be established and may represent a novel inhibitory mechanism in the osteoclast.
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Cites
Stimulatory effect of zinc on bone formation in tissue culture
Yamaguchi, M., Oishi, H., & Suketa, Y. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90471-0 · Cited by 421
Resorption of bone by isolated rabbit osteoclasts
Chambers, T. J., Revell, P. A., Fuller, K., & Athanasou, N. A. (1984) · Journal of Cell Science · doi:10.1242/jcs.66.1.383 · Cited by 413
Effect of pH on Bone Resorption by Rat Osteoclasts in Vitro
ARNETT, T. R., & DEMPSTER, D. W. (1986) · Endocrinology · doi:10.1210/endo-119-1-119 · Cited by 345
Self-citationResorption of dentine by isolated osteoclasts in vitro
Boyde, A., Ali, N. N., & Jones, S. J. (1984) · British Dental Journal · doi:10.1038/sj.bdj.4805313 · Cited by 292
Newer Aspects of the Roles of Zinc, Manganese, and Copper in Human Nutrition
Burch, R. E., Hahn, H. K. J., & Sullivan, J. F. (1975) · Clinical Chemistry · doi:10.1093/clinchem/21.4.501 · Cited by 235
Control of Cytosolic Free Calcium in Rat and Chicken Osteoclasts
Malgaroli, A., Meldolesi, J., Zallone, A. Z., & Teti, A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71683-9 · Cited by 228
‘Calcium-activated’ intracellular calcium elevation: A novel mechanism of osteoclast regulation
Zaidi, M., Datta, H. K., Patchell, A., Moonga, B., & MacIntyre, I. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91143-1 · Cited by 213
Self-citationMoonga, B. S., Moss, D. W., Patchell, A., & Zaidi, M. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018242 · Cited by 118
Self-citationDISTRIBUTION OF ZINC IN BONE TISSUE
Haumont, S. M. (1961) · Journal of Histochemistry & Cytochemistry · doi:10.1177/9.2.141 · Cited by 102
Zaidi, M., Kerby, J., Huang, C. L.-H., Alam, A. S. M. T., Rathod, H., Chambers, T. J., & Moonga, B. S. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041490310 · Cited by 95
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Substituted hydroxyapatites for bone repair
Shepherd, J. H., Shepherd, D. V., & Best, S. M. (2012) · Journal of Materials Science: Materials in Medicine · doi:10.1007/s10856-012-4598-2 · Cited by 321
Wang, S., Gu, R., Wang, F., Zhao, X., Yang, F., Xu, Y., Yan, F., Zhu, Y., Xia, D., & Liu, Y. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100202 · Cited by 115
Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue
Ciosek, Ż., Kot, K., & Rotter, I. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20032197 · Cited by 86
Metadata
- Authors
- Moonga, B. S., & Dempster, D. W.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-03-01
- Volume
- 10
- Issue
- 3
- Pages
- 453-457
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2019305463
- Cited by
- 314
- References
- 16
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moonga, B. S., & Dempster, D. W. (1995). Zinc is a potent inhibitor of osteoclastic bone resorption in vitro. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.5650100317
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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