Mice Brain Tissue Injury Induced by Diisononyl Phthalate Exposure and the Protective Application of Vitamin E: BRAIN INJURY INDUCED BY DIISONONYL PHTHALATE
Abstract
As a widely used plasticizer in plastic industry, the data of diisononyl phthalate (DINP) toxicity due to exposure are insufficient. This work investigated the brain tissue injury induced by DINP exposure. Through oral exposure to DINP, oxidative stress, inflammatory responses, apoptosis, and hippocampus pathological alterations were found in the mice brain. And through the Morris water maze test, cognitive deficits were tested. Our data also showed that these exacerbations were counteracted by vitamin E. These results above indicated that oral exposure of mice to DINP induced brain damage, and oxidative stress, inflammation, and the consequential apoptosis jointly constituted the potential mechanisms of such induced toxicity.
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After oral administration, DINP causes brain damage in mice characterized by increased oxidative stress, neuroinflammation, and apoptosis.
“After oral administration, DINP causes brain damage in mice characterized by increased oxidative stress, neuroinflammation, and apoptosis (Peng, 2015).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Peng, 2015
Cites
Zola-Morgan, S., Squire, L., & Amaral, D. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02950.1986 · Cited by 1,997 · see citing works
Xiao, G. G., Wang, M., Li, N., Loo, J. A., & Nel, A. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306423200 · Cited by 428 · see citing works
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Seralini, G.-E., & Jungers, G. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.07.014 · Cited by 57 · see citing works
Jocsak, G., Kiss, D. S., Alymbaeva, D., Diebald, A., Zsarnovszky, A., Heinzlmann, A., & Bartha, T. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1821381 · Cited by 1 · see citing works
“After oral administration, DINP causes brain damage in mice characterized by increased oxidative stress, neuroinflammation, and apoptosis (Peng, 2015).”
- Authors
- Peng, L.
- Affiliations
- Yichun University (CN)
- Corresponding author
- Peng, Ling
- ORCID
- Peng, Ling
- Venue
- Journal of Biochemical and Molecular Toxicology
- Publisher
- Wiley
- Published
- 2015-04-23
- Volume
- 29
- Issue
- 7
- Pages
- 311-320
- ISSN
- 0887-2082 (ISSN-L)
- 1095-6670
- OpenAlex
- W1884267928
- Cited by
- 30
- References
- 2
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biochemical and Molecular Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Keywords
- diisononyl phthalate, plasticizer toxicity, brain tissue injury, vitamin E, oxidative stress, neuroinflammation, apoptosis, hippocampus, cognitive impairment, oral exposure, neuroprotection
- MeSH terms
- Animals, Brain Injuries, Inflammation, Male, Phthalic Acids, Vitamin E, Apoptosis, Oxidative Stress, Protective Agents, Mice
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