The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Suppression of microRNA‐144‐3p attenuates oxygen–glucose deprivation/reoxygenation‐induced neuronal injury by promoting Brg1/Nrf2/ARE signaling
Abstract
Accumulating evidence has reported that microRNA‐144‐3p (miR‐144‐3p) is highly related to oxidative stress and apoptosis. However, little is known regarding its role in cerebral ischemia/reperfusion‐induced neuronal injury. Herein, our results showed that miR‐144‐3p expression was significantly downregulated in neurons following oxygen–glucose deprivation and reoxygenation (OGD/R) treatment. Overexpression of miR‐144‐3p markedly reduced cell viability, promoted cell apoptosis, and increased oxidative stress in neurons with OGD/R treatment, whereas downregulation of miR‐144‐3p protected neurons against OGD/R‐induced injury. Brahma‐related gene 1 (Brg1) was identified as a potential target gene of miR‐144‐3p. Moreover, downregulation of miR‐144‐3p promoted the nuclear translocation of nuclear factor erythroid 2‐related factor 2 (Nrf2) and increased antioxidant response element (ARE) activity. However, knockdown of Brg1 significantly abrogated the neuroprotective effects of miR‐144‐3p downregulation. Overall, our results suggest that miR‐144‐3p contributes to OGD/R‐induced neuronal injury in vitro through negatively regulating Brg1/Nrf2/ARE signaling.
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“mmu-miR-7a-2-3p [56] and mmu-miR-144-3p [57] were shown to be downregulated in primary neurons after oxygen–glucose deprivation (OGD), but overexpression of these two miRNAs resolved the hypoxia–ischemia-induced neuronal apoptosis.”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [57]
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Research works printed but not linked: 1
- Zhao Y., 2017, Am. J. Transl. Res., 9, 2437
Cited by
Differential RNA packaging into small extracellular vesicles by neurons and astrocytes
Luo, X., Jean-Toussaint, R., Sacan, A., & Ajit, S. K. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00757-4 · Cited by 32
Metadata
- Authors
- Li, Y., Zhao, Y., Cheng, M., Qiao, Y., Wang, Y., Xiong, W., & Yue, W.
- Affiliations
- Department of Critical Care Medicine The First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan 453100 China
- Department of Intervention The First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan 453100 China
- Department of General Surgery The First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan 453100 China
- Department of Imaging Xinxiang Medical University Xinxiang Henan 453003 China
- ORCID
- Yue, Wei
- Venue
- Journal of Biochemical and Molecular Toxicology
- Publisher
- Wiley
- Published
- 2018-02-19
- Volume
- 32
- Issue
- 4
- ISSN
- 1095-6670
- 1099-0461
- Cited by
- 47
- References
- 35
- Language
- en
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- Li, Y., Zhao, Y., Cheng, M., Qiao, Y., Wang, Y., Xiong, W., & Yue, W. (2018). Suppression of microRNA‐144‐3p attenuates oxygen–glucose deprivation/reoxygenation‐induced neuronal injury by promoting Brg1/Nrf2/ARE signaling. Journal of Biochemical and Molecular Toxicology. https://doi.org/10.1002/jbt.22044
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