Trimethylamine N‐oxide as a risk marker for ischemic stroke in patients with atrial fibrillation
Open accessAbstract
Trimethylamine N‐oxide (TMAO) is an independent risk factor of cardiovascular disease. Our objective was to explore the relation between TMAO and ischemic stroke (IS) in patients with atrial fibrillation (AF). A total of 68 patients with AF with IS and 111 ones without IS were enrolled. The plasma levels of TMAO remarkably increased in IS‐AF patients (8.25 ± 1.58 µM) compared with patients with AF (2.22 ± 0.09 µM, P < 0.01). The receiver operating characteristic analysis revealed that the best cutoff value of TMAO to predict IS in patients with AF was 3.53 µM with 75.0% sensitivity and 92.8% specificity (area under the curve: 0.917, 95% confidence intervals: 0.877‐0.957). Univariate and multivariate logistic regression analysis showed that TMAO was an independent predictor in IS. The level of TMAO was correlated with the CHA2DS2‐VASc score. In conclusion, TMAO was an independent predictor of IS, which could potentially refine stroke stratification in patients with AF.
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TMAO was an independent predictor of ischemic stroke among patients with atrial fibrillation.
“A prediction model reported that TMAO was an independent predictor of ischemic stroke among patients with atrial fibrillation.25”
From Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years (2021) · cites this paper as [25]
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Farhangi, M. A., Vajdi, M., & Asghari-Jafarabadi, M. (2020) · Nutrition Journal · doi:10.1186/s12937-020-00592-2 · Cited by 72 · see citing works
Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years
Lee, G., Choi, S., Chang, J., Choi, D., Son, J. S., Kim, K., Kim, S. M., Jeong, S., & Park, S. M. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.36008 · Cited by 37 · see citing works
- Authors
- Liang, Z., Dong, Z., Guo, M., Shen, Z., Yin, D., Hu, S., & Hai, X.
- Affiliations
- First Affiliated Hospital of Harbin Medical University (CN)
- Harbin Medical University (CN)
- Corresponding author
- Hai, Xin
- Venue
- Journal of Biochemical and Molecular Toxicology
- Publisher
- Wiley
- Published
- 2018-10-28
- Volume
- 33
- Issue
- 2
- Pages
- e22246-e22246
- ISSN
- 0887-2082 (ISSN-L)
- 1095-6670
- 1099-0461
- OpenAlex
- W2898744567
- Cited by
- 57
- References
- 8
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 5
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biochemical and Molecular Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81700151, 81870169, 81400250)
- Natural Science Foundation of Heilongjiang Province (H2017040)
- Health and Family Planning Commission of Heilongjiang Province (GC12C3056)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- trimethylamine N-oxide, ischemic stroke, atrial fibrillation, stroke risk markers, CHA2DS2-VASc score, stroke risk stratification, cardiovascular risk factors
- MeSH terms
- Aged, Atrial Fibrillation, Brain Ischemia, Female, Humans, Male, Methylamines, Middle Aged, Risk Factors, Biomarkers, Stroke
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