The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of skeletal development by the Runx family of transcription factors
Abstract
The Runx (runt-related protein) family of transcription factors plays important roles in different tissues and cell lineages. Runx1 determines commitment to the hematopoietic cell lineage and Runx2 determines commitment to the osteoblastic lineage. Cbfbeta is required for Runx1- and Runx2-dependent transcriptional regulation. Runx2 interacts with many other transcription factors and co-regulators in the transcriptional regulation of its target genes. Runx2 is essential for the commitment of multipotent mesenchymal cells into the osteoblastic lineage and inhibits adipocyte differentiation. Runx2 induces the gene expression of bone matrix proteins, while keeping the osteoblastic cells in an immature stage. Runx2 and Runx3 have redundant functions in chondrocytes, and they are essential for chondrocyte maturation. Runx2 directly induces Indian hedgehog (Ihh) expression and co-ordinates the proliferation and differentiation of chondrocytes. Therefore, elucidation of the signaling pathways through Runx2 and Runx3 will unravel the complex mechanism of skeletal development.
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Cites
Thomas, D. M., Carty, S. A., Piscopo, D. M., Lee, J.-S., Wang, W.-F., Forrester, W. C., & Hinds, P. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00327-6 · Cited by 361
Cited by
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170
The cell biology of bone metabolism
Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048868 · Cited by 614
Saito, T., Fukai, A., Mabuchi, A., Ikeda, T., Yano, F., Ohba, S., Nishida, N., Akune, T., Yoshimura, N., Nakagawa, T., et al. (2010) · Nature Medicine · doi:10.1038/nm.2146 · Cited by 532
Signaling networks in RUNX2‐dependent bone development
Komori, T. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22994 · Cited by 329
Self-citationHypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression
Potier, E., Ferreira, E., Andriamanalijaona, R., Pujol, J.-P., Oudina, K., Logeart-Avramoglou, D., & Petite, H. (2007) · Bone · doi:10.1016/j.bone.2006.11.024 · Cited by 294
Metadata
- Authors
- Komori, T.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2005
- Volume
- 95
- Issue
- 3
- Pages
- 445-453
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2028122458
- Cited by
- 330
- References
- 1
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
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