The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Functional properties and intracellular signaling of CCN1/Cyr61
Abstract
CCN1/Cyr61 is a member of the protein family that can be promptly induced by growth factors. CCN1/Cyr61 promotes cell proliferation, adhesion, and differentiation. It plays important roles in angiogenesis and extracellular matrix production. In addition, CCN1/Cyr61 has many potential functions in tumorigenesis, development, embryo implantation, as well as formation of endometriotic lesions. Expression of CCN1/Cyr61 is regulated by a variety of agents including cytokines, growth factors, steroid hormones, and some drugs. These inducers regulate the transcription of CCN1/Cyr61 through several signaling transduction pathways. CCN1/Cyr61 is able to interact either with the cell itself or the surrounding cells through an autocrine–paracrine mechanism. It has been reported that CCN1/Cyr61 exerts its functions via interacting with at least five integrins as well as heparan sulfate proteoglycan. By activating Wnt, NF‐kappaB, or tyrosine kinase signaling pathways, CCN1/Cyr61 is not only able to control the growth of epithelial cells and fibroblasts, but also induce or suppress apoptosis in a cell type‐specific manner. J. Cell. Biochem. 100: 1337–1345, 2007. © 2006 Wiley‐Liss, Inc.
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1 retracted
Tong, X., O'Kelly, J., Xie, D., Mori, A., Lemp, N., McKenna, R., Miller, C. W., & Koeffler, H. P. (2004) · Oncogene · doi:10.1038/sj.onc.1207628 · Cited by 86
RetractedCYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity
Mo, F.-E., Muntean, A. G., Chen, C.-C., Stolz, D. B., Watkins, S. C., & Lau, L. F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8709-8720.2002 · Cited by 416
Expression of cyr61, a growth factor-inducible immediate-early gene.
O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3569 · Cited by 310
The Angiogenic Factor Cyr61 Activates a Genetic Program for Wound Healing in Human Skin Fibroblasts
Chen, C.-C., Mo, F.-E., & Lau, L. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107666200 · Cited by 300
Si, W., Kang, Q., Luu, H. H., Park, J. K., Luo, Q., Song, W.-X., Jiang, W., Luo, X., Li, X., Yin, H., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2955-2964.2006 · Cited by 272
Schober, J. M., Chen, N., Grzeszkiewicz, T. M., Jovanovic, I., Emeson, E. E., Ugarova, T. P., Ye, R. D., Lau, L. F., & Lam, S. C.-T. (2002) · Blood · doi:10.1182/blood.v99.12.4457 · Cited by 242
Lin, M.-T., Chang, C.-C., Chen, S.-T., Chang, H.-L., Su, J.-L., Chau, Y.-P., & Kuo, M.-L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402305200 · Cited by 194
Xie, D., Miller, C. W., O'Kelly, J., Nakachi, K., Sakashita, A., Said, J. W., Gornbein, J., & Koeffler, H. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009755200 · Cited by 146
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The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts
Todorovicç, V., Chen, C.-C., Hay, N., & Lau, L. F. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504015 · Cited by 132
Cited by
Su, J.-L., Chiou, J., Tang, C.-H., Zhao, M., Tsai, C.-H., Chen, P.-S., Chang, Y.-W., Chien, M.-H., Peng, C.-Y., Hsiao, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.087122 · Cited by 121
Dobroff, A. S., Wang, H., Melnikova, V. O., Villares, G. J., Zigler, M., Huang, L., & Bar-Eli, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019836 · Cited by 89
Alternative Splicing of Cyr61 Is Regulated by Hypoxia and Significantly Changed in Breast Cancer
Hirschfeld, M., zur Hausen, A., Bettendorf, H., Jäger, M., & Stickeler, E. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1997 · Cited by 86
Kivelä, R., Kyröläinen, H., Selänne, H., Komi, P. V., Kainulainen, H., & Vihko, V. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00531.2007 · Cited by 66
G Protein-Coupled Receptors Go Extracellular: RhoA Integrates the Integrins
Walsh, C. T., Stupack, D., & Brown, J. H. (2008) · Molecular Interventions · doi:10.1124/mi.8.4.8 · Cited by 40
Metadata
- Authors
- Chen, Y., & Du, X.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2006-12-14
- Volume
- 100
- Issue
- 6
- Pages
- 1337-1345
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2047781799
- Cited by
- 167
- References
- 20
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
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