The DOI matches its Crossref record.
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues
Open accessAbstract
Periostin is predominantly expressed in collagen‐rich fibrous connective tissues that are subjected to constant mechanical stresses including: heart valves, tendons, perichondrium, cornea, and the periodontal ligament (PDL). Based on these data we hypothesize that periostin can regulate collagen I fibrillogenesis and thereby affect the biomechanical properties of connective tissues. Immunoprecipitation and immunogold transmission electron microscopy experiments demonstrate that periostin is capable of directly interacting with collagen I. To analyze the potential role of periostin in collagen I fibrillogenesis, gene targeted mice were generated. Transmission electron microscopy and morphometric analyses demonstrated reduced collagen fibril diameters in skin dermis of periostin knockout mice, an indication of aberrant collagen I fibrillogenesis. In addition, differential scanning calorimetry (DSC) demonstrated a lower collagen denaturing temperature in periostin knockout mice, reflecting a reduced level of collagen cross‐linking. Functional biomechanical properties of periostin null skin specimens and atrioventricular (AV) valve explant experiments provided direct evidence of the role that periostin plays in regulating the viscoelastic properties of connective tissues. Collectively, these data demonstrate for the first time that periostin can regulate collagen I fibrillogenesis and thereby serves as an important mediator of the biomechanical properties of fibrous connective tissues. J. Cell. Biochem. 101: 695–711, 2007. © 2007 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Woodruff, P. G., Boushey, H. A., Dolganov, G. M., Barker, C. S., Yang, Y. H., Donnelly, S., Ellwanger, A., Sidhu, S. S., Dao-Pick, T. P., Pantoja, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707413104 · Cited by 828
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
Fu, X., Khalil, H., Kanisicak, O., Boyer, J. G., Vagnozzi, R. J., Maliken, B. D., Sargent, M. A., Prasad, V., Valiente-Alandi, I., Blaxall, B. C., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98215 · Cited by 636
Self-citationOka, T., Xu, J., Kaiser, R. A., Melendez, J., Hambleton, M., Sargent, M. A., Lorts, A., Brunskill, E. W., Dorn, G. W., Conway, S. J., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.149047 · Cited by 494
Self-citationTeekakirikul, P., Eminaga, S., Toka, O., Alcalai, R., Wang, L., Wakimoto, H., Nayor, M., Konno, T., Gorham, J. M., Wolf, C. M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42028 · Cited by 448
Self-citationMyocardial Extracellular Matrix: An Ever-Changing and Diverse Entity
Rienks, M., Papageorgiou, A.-P., Frangogiannis, N. G., & Heymans, S. (2014) · Circulation Research · doi:10.1161/circresaha.114.302533 · Cited by 366
Metadata
- Authors
- Norris, R. A., Damon, B., Mironov, V., Kasyanov, V., Ramamurthi, A., Moreno‐Rodriguez, R., Trusk, T., Potts, J. D., Goodwin, R. L., Davis, J., Hoffman, S., Wen, X., Sugi, Y., Kern, C. B., Mjaatvedt, C. H., Turner, D. K., Oka, T., Conway, S. J., Molkentin, J. D., Forgacs, G., & Markwald, R. R.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2007-01-16
- Volume
- 101
- Issue
- 3
- Pages
- 695-711
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2035371717
- Cited by
- 601
- References
- 0
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. https://app.cochat.ai/papers/10.1002/jcb.21224
- The paper
- Norris, R. A., Damon, B., Mironov, V., Kasyanov, V., Ramamurthi, A., Moreno‐Rodriguez, R., Trusk, T., Potts, J. D., Goodwin, R. L., Davis, J., Hoffman, S., Wen, X., Sugi, Y., Kern, C. B., Mjaatvedt, C. H., Turner, D. K., Oka, T., Conway, S. J., Molkentin, J. D., . . . Markwald, R. R. (2007). Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.21224
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
