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Applications of immortalized cells in basic and clinical neurology

Geller, Herbert M., Quiñ;ones‐Jenab, Vanya, Poltorak, Maciej, Freed, William J.·1991·Journal of Cellular Biochemistry
DOI 10.1002/jcb.240450310
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Abstract

Immortalized cell lines can serve as model systems for studies of neuronal development and restoration of function in models of neurological disease. Cell lines which result from spontaneous or experimentally‐induced tumors have been used for these purposes. More recently, the techniques of genetic engineering have resulted in the production of cell lines with specific desired characteristics. This has been accomplished by insertion of a desired gene into a pre‐existing immortal cell or by immortalizing primary cells. The production of immortal cell lines using temperature‐sensitive immortalizing genes offers an additional method of controlling gene expression, and thereby controlling cell proliferation and differentation. In the nervous system, these techniques have produced immortal cell lines with neuronal and glial properties.

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Metadata

Authors
Geller, H. M., Quiñ;ones‐Jenab, V., Poltorak, M., & Freed, W. J.
Venue
Journal of Cellular Biochemistry
Publisher
Wiley
Published
1991-03
Volume
45
Issue
3
Pages
279-283
ISSN
  • 0730-2312
  • 1097-4644
DOI
10.1002/jcb.240450310
Cited by
10
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4738 d)

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