The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis
Abstract
Capillary endothelial (CE) cells require two extracellular signals in order to switch from quiescence to growth and back to differentiation during angiogenesis: soluble angiogenic factors and insoluble extracellular matrix (ECM) molecules. Soluble endothelial mitogens, such as basic fibroblast growth factor (FGF), act over large distances to trigger capillary growth, whereas ECM molecules act locally to modulate cell responsiveness to these soluble cues. Recent studies reveal that ECM molecules regulate CE cell growth and differentiation by modulating cell shape and by activating intracellular chemical signaling pathways inside the cell. Recognition of the importance of ECM and cell shape during capillary morphogenesis has led to the identification of a series of new angiogenesis inhibitors. Elucidation of the molecular mechanism of capillary regulation may result in development of even more potent angiogenesis modulators in the future.
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Cites
Opas, M. (1989) · Developmental Biology · doi:10.1016/s0012-1606(89)80001-6 · Cited by 114
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Brooks, P. C., Clark, R. A. F., & Cheresh, D. A. (1994) · Science · doi:10.1126/science.7512751 · Cited by 3,020
Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262
Biological Roles of Fibroblast Growth Factor-2*
Bikfalvi, A., Klein, S., Pintucci, G., & Rifkin, D. B. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0292 · Cited by 959
Brown, B. N., Valentin, J. E., Stewart-Akers, A. M., McCabe, G. P., & Badylak, S. F. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.11.040 · Cited by 896
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Metadata
- Authors
- Ingber, D.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 1991-11
- Volume
- 47
- Issue
- 3
- Pages
- 236-241
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2052766257
- Cited by
- 242
- References
- 1
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ingber, D. (1991). Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.240470309
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
