20‐O‐β‐d‐Glucopyranosyl‐20(S)‐Protopanaxadiol Suppresses UV‐Induced MMP‐1 Expression Through AMPK‐Mediated mTOR Inhibition as a Downstream of the PKA‐LKB1 Pathway

Shin, Dong Joo; Kim, Jong‐Eun; Lim, Tae‐Gyu; Jeong, Eun Hee; Park, Gaeun; Kang, Nam Joo; Park, Jun‐Seong; Yeom, Myeong‐Hun; Oh, Deok Kun; Bode, Ann M.; Dong, Zigang; Lee, Hyong Joo; Lee, Ki Won

doi:10.1002/jcb.24833

20‐O‐β‐d‐Glucopyranosyl‐20(S)‐Protopanaxadiol Suppresses UV‐Induced MMP‐1 Expression Through AMPK‐Mediated mTOR Inhibition as a Downstream of the PKA‐LKB1 Pathway

Various health effects have been attributed to the ginsenoside metabolite 20‐ O ‐β‐D‐glucopyranosyl‐20(S)‐protopanaxadiol (GPD); however, its effect on ultraviolet (UV)‐induced matrix metalloproteinase (MMP)‐1 expression and the mechanism underlying this effect are unknown. We examined the inhibi…