A study on correlation between oxidative stress parameters and inflammatory markers in type 2 diabetic patients with kidney dysfunction in north Indian population
Abstract
Background Research reports support the statement that oxidative stress and inflammation are well-known risk factors for chronic kidney disease (CKD) in patients with diabetes. This study was designed to ascertain the associated role of oxidative stress parameters and inflammatory markers in diabetes and related CKD among the north Indian population. Methods The study was divided into three groups as healthy subjects (group 1), patients with diabetes without complication (group 2), and with CKD (group 3). Serum levels of malondialdehyde (MDA) and nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR) content were estimated in all individuals. Inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)-α were determined by enzyme-linked immuno-sorbent assay. Results MDA, protein carbonyl, and NO were significantly elevated in patients with type 2 diabetes as compared with healthy subjects (P ≤ 0.05). Total thiols content were found to be significantly decreased in patients with diabetes with CKD. The activity of antioxidant enzymes SOD, CAT, and GR showed a significant suppression in patients with type 2 diabetes with or without CKD as compared with healthy subjects. Nevertheless, the levels of proinflammatory cytokines IL-6 and TNF-α were significantly upregulated ( P ≤ 0.05) as compared with healthy subjects. Conclusion Determination of antioxidant defense parameters and inflammatory markers contributes to understand…
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Plasma MDA levels are higher in T2D patients with or without CKD (n = 50 per group) than in healthy control subjects, as measured by TBARS assay.
“| T2D and CKD | Plasma | Healthy subjects vs. T2D patients with or w/o CKD (n = 50 per group) | TBARS assay | Higher MDA levels in T2D patients with and w/o CKD compared to control subjects | [219] |”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [219]
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- Authors
- Neelofar, K., Arif, Z., Arafat, M. Y., Alam, K., & Ahmad, J.
- Affiliations
- Aligarh Muslim University (IN)
- University of Maryland, Baltimore (US)
- Corresponding author
- Neelofar, Km
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2018-09-27
- Volume
- 120
- Issue
- 4
- Pages
- 4892-4902
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2892915260
- Cited by
- 28
- References
- 69
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 2
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- type 2 diabetes, chronic kidney disease, oxidative stress, inflammation, malondialdehyde, nitric oxide, superoxide dismutase, catalase, glutathione reductase, protein carbonyls, total thiol, interleukin-6, TNF-α, antioxidant enzymes, North Indian population
- MeSH terms
- Catalase, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Glutathione Reductase, Humans, India, Male, Malondialdehyde, Middle Aged, Nitric Oxide, Superoxide Dismutase, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Oxidative Stress
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