Antibodies to viral antigens, xenoantigens, and autoantigens in Alzheimer’s disease
Abstract
Sera from 19 patients with Alzheimer's disease (AD) and 21 control subjects were studied by immunofluorescence and enzyme immunnoassay for antibody activity against various viruses and 12 self‐ and non‐self‐antigens. Total IgG mean level was significantly higher in the AD group; the IgG level was above 15 g/L in 52.8% of AD patients versus 14.3% of control subjects. Antiviral antibody titers showed no significant differences except for antibodies to herpes simplex virus‐1, which were increased in control group. In contrast, autoantibodies were more frequently found in AD patients, and the prevalence of antibodies to spectrin, peroxidase, and thyroglobulin was significantly increased. Thus, in our series, autoimmune but not antiviral responses were heightened in at least 42% of AD patients (versus 9% of the control group) suggesting the existence of two sub‐populations in the AD group.
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Earlier studies found substantial differences in IgG titers in AD patients compared to controls, but subsequent studies found no association in ante-mortem or post-mortem AD versus controls for CMV.
“Although earlier studies found substantial differences in IgG titers in AD patients compared to controls [51], subsequent studies found no association in ante-mortem [52] or post-mortem [53] AD versus controls for CMV.”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [51]
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References 68 · Cited by 58
- Authors
- Ounanian, A., Seigneurin, J. ‐., Guilbert, B., Avrameas, S., & Renverez, J. ‐.
- Affiliations
- Centre Hospitalier Universitaire de Grenoble (FR)
- Institut Pasteur (FR)
- Corresponding author
- Ounanian, A.
- Venue
- Journal of Clinical Laboratory Analysis
- Publisher
- Wiley
- Published
- 1990-01
- Volume
- 4
- Issue
- 5
- Pages
- 367-375
- ISSN
- 0887-8013 (ISSN-L)
- 1098-2825
- OpenAlex
- W2146911578
- Cited by
- 58
- References
- 68
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 2 · 2021: 14 · 2020: 4 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Laboratory Analysis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Keywords
- Alzheimer's disease, autoantibodies, antiviral antibodies, xenoantigens, autoantigens, IgG levels, herpes simplex virus type 1, spectrin, peroxidase, thyroglobulin, autoimmunity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Antibodies, Viral, Antigens, Viral, Autoantibodies, Autoantigens, Autoimmune Diseases, Blood Proteins, Cytomegalovirus, Electrophoresis, Cellulose Acetate, Female, Humans, Immunoglobulin G, Immunoenzyme Techniques, Male, Middle Aged, Herpesvirus 3, Human, Antigens, Heterophile, Simplexvirus
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