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Cited by 133Bone Metabolism and DiseasesCell Adhesion Molecules ResearchBone and Dental Protein Studies

The DOI matches its Crossref record; 83 of the 86 references it cites were found in a registry or an index.

Role of N‐cadherin in bone formation

Marie, Pierre J.·2002·Journal of Cellular Physiology
DOI 10.1002/jcp.10073
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Abstract

Cell–cell adhesion mediated by cadherins is essential for the function of bone forming cells during osteogenesis. Here, the evidence that N‐cadherin is an important regulator of osteoblast differentiation and osteogenesis is reviewed. Osteoblasts express a limited number of cadherins, including the classic N‐cadherin. The expression profile of N‐cadherin in osteoblasts during bone formation in vivo and in vitro suggests a role of this molecule in osteogenesis. Functional studies using neutralizing antibodies or antisense oligonucleotides indicate that N‐cadherin is involved in the control the expression of osteoblast marker gene expression and differentiation. Cleavage of N‐cadherin during osteoblast apoptosis also suggests a role of N‐cadherin‐mediated‐cell–cell adhesion in osteoblast survival. Hormonal and local factors that regulate osteoblast function also regulate N‐cadherin expression and subsequent cell–cell adhesion associated with osteoblast differentiation or survival. Signaling mechanisms involved in N‐cadherin‐mediated cell–cell adhesion and osteoblast gene expression have also been identified. Alterations of N‐cadherin expression are associated with abnormal osteoblast differentiation and osteogenesis in pathological conditions. These findings indicate that N‐cadherin plays a role in normal and pathological bone formation and provide some insight into the process involved in N‐cadherin‐mediated cell–cell adhesion and differentiation in osteoblasts. J. Cell. Physiol. 190: 297–305, 2002. © 2002 Wiley‐Liss, Inc.

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Crossref · 10.1002/jcp.10073

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Citations

Cites

Show all 86 references

Research works printed but not linked: 8

  1. Globus RK, 1995, Integrin‐extracellular matrix interactions in connective tissue remodeling and osteoblast differentiation, ASGSB Bull, 8, 19
  2. 10.1002/(SICI)1097-4644(1998)72:30/31 <168::AID-JCB21>3.0.CO;2-V · DOI
  3. Le Mée S, 2001, Cloning of the human N‐cadherin promoter: functional analysis of a G.C‐rich region and regulatory elements [abstract], J Bone Miner Res, 16, S489
  4. Lomri A, 1998, Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor‐2 mutations in Apert syndrome, J Clin Invest, 101, 1310
  5. Marie PJ, 1997, Effects of bone morphogenetic proteins on cells of the osteoblastic lineage, J Cell Eng, 2, 92
  6. Marie PJ, 1999, Advances in organ biology: molecular and cellular biology of bone, 401
  7. Suva LJ, 1994, Hormonal regulation of osteoblast‐derived cadherin expression in vitro and in vivo, J Bone Miner Res, 9, S123
  8. Triffitt JT, 1996, Principles of bone biology, 39

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Related

Metadata

Authors
Marie, P. J.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Marie, Pierre J.
Venue
Journal of Cellular Physiology
Publisher
Wiley
Published
2002-01-24
Volume
190
Issue
3
Pages
297-305
ISSN
  • 0021-9541 (ISSN-L)
  • 1097-4652
DOI
10.1002/jcp.10073
OpenAlex
W2052361599
Cited by
132
References
86
Citations by year
2025: 2 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 7
FWCI
0.55
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Cellular Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords
N-cadherin, bone formation, osteogenic differentiation, cell-cell adhesion, osteoblast apoptosis, osteoblast survival, cadherin signaling
MeSH terms
Animals, Bone Diseases, Cell Adhesion, Cell Differentiation, Humans, Osteoblasts, Osteogenesis, Cadherins, Chondrogenesis

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