The DOI matches its Crossref record.
A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication‐stimulating activity for embryo fibroblasts
Abstract
A polypeptide fraction with multiplication‐stimulating activity for chicken and rat embryo fibroblasts was partially purified from serum‐free medium conditioned by the growth of a line of rat liver cells. The specific multiplication‐stimulating activity of this fraction was 27,000 times that of serum. The rat liver cell multiplication‐stimulating activity had a molecular weight of approximately 10,000 daltons and was inactivated by mercaptoethanol and dithiothreitol. It had sulfation factor and non‐suppressible insulin‐like activities, but did not have anti‐trypsin activity. The rat liver cell multiplication‐stimulating activity resembled both multiplication‐stimulating activity from calf serum and somatomedin.
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Citations
Cited by
Growth factors: Mechanism of action and relation to oncogenes
Heldin, C.-H., & Westermark, B. (1984) · Cell · doi:10.1016/0092-8674(84)90296-4 · Cited by 854
Membrane Receptors and Hormone Action
Cuatrecasas, P., & Hollenberg, M. D. (1976) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60481-7 · Cited by 478
Effect of conditioned media on nerve cell differentiation
Sensenbrenner, M., Jaros, G. G., Moonen, G., & Meyer, B. J. (1980) · Experientia · doi:10.1007/bf01970123 · Cited by 34
Metadata
- Authors
- Dulak, N. C., & Temin, H. M.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1973-04
- Volume
- 81
- Issue
- 2
- Pages
- 153-160
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W1989370995
- Cited by
- 334
- References
- 0
- FWCI
- 28.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication‐stimulating activity for embryo fibroblasts. https://app.cochat.ai/papers/10.1002/jcp.1040810204
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- Dulak, N. C., & Temin, H. M. (1973). A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication‐stimulating activity for embryo fibroblasts. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1040810204
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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