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Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts
Abstract
Human diploid fibroblasts utilize both glucose and glutamine as energy sources. The utilization of glutamine by fibroblasts is regulated by glucose, and vice versa. This conclusion is supported by the following observations: (1) essentially identical growth rates were observed in Eagle's minimum essential medium (MEM)3 in which the glucose concentration was either 5.5 mM or was maintained between 25 and 40 μM, (2) the total glutamine utilization by fibroblasts increased at least 30% in medium with 25 μM to 70 μM glucose compared to medium with 5.5 mM glucose, while the rate of glutamine‐1 or 5‐14 C oxidation to CO 2 increased 5‐fold as the glucose concentration was decreased to zero, (3) 2 mM glutamine inhibited glucose‐6‐14 C oxidation by 88% and stimulated glucose‐1‐14 C by 77% in log phase cells and (4) glutamine oxidation in normal medium contributed approximately 30% of the energy requirement of human diploid fibroblasts.
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Citations
Cited by
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057
An improved culture medium supports development of random-bred 1-cell mouse embryos in vitro
Chatot, C. L., Ziomek, C. A., Bavister, B. D., Lewis, J. L., & Torres, I. (1989) · Reproduction · doi:10.1530/jrf.0.0860679 · Cited by 1,114
Timmerman, L. A., Holton, T., Yuneva, M., Louie, R. J., Padró, M., Daemen, A., Hu, M., Chan, D. A., Ethier, S. P., van ‘t Veer, L. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.08.020 · Cited by 573
“Also, naturally-arising tumors without dominant oncogenic driver may overcome nutrient scarcity by switching nutrient sources (Zielke et al., 1978), attenuating cell cycle progression (Jones et al.”
InfluentialThe role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
Newsholme, E. A., Crabtree, B., & Ardawi, M. S. M. (1985) · Bioscience Reports · doi:10.1007/bf01116556 · Cited by 364
Glacken, M. W., Fleischaker, R. J., & Sinskey, A. J. (1986) · Biotechnology and Bioengineering · doi:10.1002/bit.260280912 · Cited by 347
Metadata
- Authors
- Ronald Zielke, H., Ozand, P. T., Tyson Tildon, J., Sevdalian, D. A., & Cornblath, M.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1978-04
- Volume
- 95
- Issue
- 1
- Pages
- 41-48
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2141172423
- Cited by
- 273
- References
- 0
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts. https://app.cochat.ai/papers/10.1002/jcp.1040950106
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- Ronald Zielke, H., Ozand, P. T., Tyson Tildon, J., Sevdalian, D. A., & Cornblath, M. (1978). Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1040950106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
