The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5
Abstract
The SV40 transformed murine macrophage cell line, BAC1, proliferates in response to the colony stimulating factor, CSF‐1 (Schwarzbaum et al., J. Immunol., 132:1158, 1984). In order to obtain a cell line suitable for biochemical and genetic studies of CSF‐1 signal transduction, clones of BAC1 were established. Clones ranged from being completely autonomous to being completely dependent on CSF‐1 for growth. Cells of one clone (2F5), which proliferated in response to either CSF‐1 or granulocyte‐macrophage CSF (GM‐CSF) were characterized in detail. The kinetics of receptor‐mediated internalization and intracellular destruction of CSF‐1 were comparable to the kinetics observed with peritoneal exudate macrophages. CSF‐1 was shown to regulate cell spreading, cell survival, protein degradation, and the duration of the G1 and S phases of the cell cycle. The 2F5 clone therefore exhibits a number of CSF‐1 stimulated responses and is being used for genetic and biochemical studies of CSF‐1 action.
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Citations
Cites
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Cited by
Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R., & Hume, D. A. (2003) · Blood · doi:10.1182/blood-2002-02-0569 · Cited by 662
Self-citationRho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages
Allen, W. E., Jones, G. E., Pollard, J. W., & Ridley, A. J. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.6.707 · Cited by 409
Self-citationWei, S., Nandi, S., Chitu, V., Yeung, Y.-G., Yu, W., Huang, M., Williams, L. T., Lin, H., & Stanley, E. R. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1209822 · Cited by 370
Self-citationPU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells
Feng, R., Desbordes, S. C., Xie, H., Tillo, E. S., Pixley, F., Stanley, E. R., & Graf, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711961105 · Cited by 348
Nandi, S., Gokhan, S., Dai, X.-M., Wei, S., Enikolopov, G., Lin, H., Mehler, M. F., & Stanley, E. R. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.026 · Cited by 344
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Metadata
- Authors
- Morgan, C., Pollard, J. W., & Stanley, E. R.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1987-03
- Volume
- 130
- Issue
- 3
- Pages
- 420-427
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2080719576
- Cited by
- 196
- References
- 1
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Morgan, C., Pollard, J. W., & Stanley, E. R. (1987). Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1041300316
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