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Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells
Abstract
A new biochemical method for estimating the virtual number of mitochondria (mt) per cell was developed and used together with a plasmid probe to measure mt DNA/mitochondrion and mt DNA/cell. These methods were used in five cell types from four mammalian species. Mt DNA/mitochondrion was essentially constant in all cell types (mean 2.6 ± 0.30 SE mitochondrial DNA molecules/mt). Mt DNA molecules/cell encompassed an eight‐fold range between various cell types (low 220 ± 6.2; high 1,720 ± 162 mt DNA molecules/cell). Virtual mt number/cell ranged from 83 ± 17 to 677 ± 80 (SE) mt/cell in various cell types. All five mammalian virtual mitochondria contained the same genomic mass. The number of virtual mitochondria per cell and amount of mt DNA per cell appear to be closely regulated within a given cell type but differ widely from cell type to cell type.
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Cann, R. L., Stoneking, M., & Wilson, A. C. (1987) · Nature · doi:10.1038/325031a0 · Cited by 3,100
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Taanman, J.-W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00161-3 · Cited by 1,635
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Linnane, A., Ozawa, T., Marzuki, S., & Tanaka, M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92145-4 · Cited by 983
Spelbrink, J. N., Li, F.-Y., Tiranti, V., Nikali, K., Yuan, Q.-P., Tariq, M., Wanrooij, S., Garrido, N., Comi, G., Morandi, L., et al. (2001) · Nature Genetics · doi:10.1038/90058 · Cited by 882
Metadata
- Authors
- Robin, E. D., & Wong, R.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1988-09
- Volume
- 136
- Issue
- 3
- Pages
- 507-513
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2070842365
- Cited by
- 650
- References
- 0
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Robin, E. D., & Wong, R. (1988). Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1041360316
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
