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Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils
Abstract
Human peripheral blood monocytes and neutrophils secrete TGF-beta. Activation of monocytes with LPS stimulates the secretion of TGF-beta; however, the production of TGF-beta by neutrophils was not altered by treatment with LPS. The secreted TGF-beta appears to be in a fully active form since acid treatment of the conditioned medium does not increase the amount of TGF-beta activity. TGF-beta 1 transcripts were detected at similar levels in both activated and nonactivated monocytes and neutrophils, suggesting that the increase in TGF-beta secretion after activation of monocytes is regulated by a posttranscriptional mechanism. Western blot analysis with anti-N-terminal TGF-beta 1 peptide antibodies indicate the leukocyte-derived TGF-beta is beta 1. In addition, TGF-beta 1 transcripts were detected in rat peritoneal macrophages and in a differentiating human hematopoietic tumor cell line (HEL). The ability of inflammatory cells such as monocytes and neutrophils to produce TGF-beta may play an important role in the function of these cells in wound repair, in the immune response, and in the pathogenesis of fibrotic diseases.
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“Both of these have also been reported to be secreted by activated neutrophils [82, 83].”
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Metadata
- Authors
- Grotendorst, G. R., Smale, G., & Pencev, D.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Grotendorst, Gary R.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1989-08
- Volume
- 140
- Issue
- 2
- Pages
- 396-402
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2042965746
- Cited by
- 262
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 11 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 6 · 2012: 7
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- TGF-beta, TGF-β1, monocytes, neutrophils, lipopolysaccharide, monocyte activation, post-transcriptional regulation, peritoneal macrophages, HEL cell line, wound healing, fibrotic diseases, immune response
- MeSH terms
- Animals, Antigen-Antibody Complex, Cell Line, Endotoxins, Gene Expression Regulation, Hematopoietic Stem Cells, Humans, Monocytes, Neutrophils, Rats, Inbred Strains, Immunoblotting, Transforming Growth Factors, Rats
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