The DOI matches its Crossref record.
Nuclear and cytoplasmic localization of different basic fibroblast growth factor species
Abstract
The subcellular distribution of basic fibroblastic growth factor (bFGF) was analyzed by subcellular fractionation and immunofluorescence to gain insight into potential mechanisms for its release from cells. Subcellular fractionation of either SK‐Hep‐1 cells or NIH 3T3 cells transfected with a bFGF cDNA revealed that the 18 kd form of bFGF was found primarily in the cytosolic fraction, whereas the 22 and 24 kd forms of bFGF were found preferentially in ribosomal and nuclear fractions. Analysis of bFGF distribution by immunofluorescence using an antibody that recognized all forms of bFGF indicated both cytoplasmic and nuclear localization but failed to reveal any growth factor in structures representing secretory vesicles. Therefore, bFGF has a distribution inconsistent with that of a secretory protein.
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Citations
Cited by
Fibroblast growth factors, their receptors and signaling
Powers, C. J., McLeskey, S. W., & Wellstein, A. (2000) · Endocrine-related cancer · doi:10.1677/erc.0.0070165 · Cited by 1,332
Nickel, W. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03577.x · Cited by 586
Mignatti, P., Morimoto, T., & Rifkin, D. B. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041510113 · Cited by 451
Self-citationSato, Y., Tsuboi, R., Lyons, R., Moses, H., & Rifkin, D. B. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.2.757 · Cited by 444
Self-citationWijelath, E. S., Carlsen, B., Cole, T., Chen, J., Kothari, S., & Hammond, W. P. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.7.871 · Cited by 63
Metadata
- Authors
- Renko, M., Quarto, N., Morimoto, T., & Rifkin, D. B.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1990-07
- Volume
- 144
- Issue
- 1
- Pages
- 108-114
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2013817382
- Cited by
- 325
- References
- 0
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Renko, M., Quarto, N., Morimoto, T., & Rifkin, D. B. (1990). Nuclear and cytoplasmic localization of different basic fibroblast growth factor species. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1041440114
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