The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
TRAIL inhibits osteoclastic differentiation by counteracting RANKL‐dependent p27Kip1 accumulation in pre‐osteoclast precursors
Abstract
Experimental evidences indicate that the TNF family member TNF‐related apoptosis inducing ligand (TRAIL) might be involved in modulating osteoclastic differentiation. The ability of recombinant soluble TRAIL to affect bone density in vivo was evaluated by using 4‐week‐old mice subcutaneously (s.c.) injected with TRAIL for 8 days. TRAIL injection induced a significant increase of tibia trabecular thickness and total bone mass in 4‐week‐old mice, accompanied by a significant decrease of TRAP serum levels, without modulation of osteocalcin and osteoprotegerin (OPG). Parallel experiments performed in vitro showed that inhibition of osteoclastic differentiation, induced by treatment of human peripheral blood osteoclast precursors with TRAIL, was associated to inhibition of receptor activator of nuclear factor kappa B ligand (RANKL)‐induced accumulation of p27 Kip1. The potential role of p27 Kip1 pathway in mediating the anti‐osteoclastic activity of TRAIL was further suggested by in vitro gene knock‐down experiments performed in osteoclast precursor cultures. Taken together, our data strongly suggest that recombinant TRAIL inhibits osteoclastogenesis by inducing the ubiquitin‐mediated degradation of p27 Kip1. J. Cell. Physiol. 214:117–125, 2008. © 2007 Wiley‐Liss, Inc.
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“Because TRAIL and RANKL are known to regulate osteoclast differentiation and survival (33–35), these findings suggest that increased RANK (tumor necrosis factor receptor superfamily member 11a) signaling may be involved in the regulation of bone growth and remodeling induced by ACVR2B/Fc.”
From Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight (2020) · cites this paper as [34]
In the citing paper
“Because TRAIL and RANKL are known to regulate osteoclast differentiation and survival (33–35), these findings suggest that increased RANK (tumor necrosis factor receptor superfamily member 11a) signaling may be involved in the regulation of bone growth and remodeling induced by ACVR2B/Fc.”
From Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight (2020) · cites this paper as [34]
Citations
Cites
Marching cubes: A high resolution 3D surface construction algorithm
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Marching cubes: A high resolution 3D surface construction algorithm
Lorensen, W. E., & Cline, H. E. (1987) · ACM SIGGRAPH Computer Graphics · doi:10.1145/37402.37422 · Cited by 8,928
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 3×
“Its cognate high affinity transmembrane receptor, receptor activator of nuclear factor kappa B (RANK) is expressed in both mature osteoclasts and their circulating precursor cells belonging to the monocytic/ macrophagic lineage (Boyle et al., 2003).”
BackgroundInfluentialOsteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
Ashkenazi, A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc821 · Cited by 1,351
Tsvetkov, L. M., Yeh, K., Lee, S.-J., Sun, H., & Zhang, H. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80290-5 · Cited by 791
The effect of a single dose of osteoprotegerin in postmenopausal women.
Bekker, P. J., Holloway, D., Nakanishi, A., Arrighi, M., Leese, P. T., & Dunstan, C. R. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.348 · Cited by 484
Jono, S., Ikari, Y., Shioi, A., Mori, K., Miki, T., Hara, K., & Nishizawà, Y. (2002) · Circulation · doi:10.1161/01.cir.0000031524.49139.29 · Cited by 484
Bisphosphonate-Induced Osteopetrosis
Whyte, M. P., Wenkert, D., Clements, K. L., McAlister, W. H., & Mumm, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa023110 · Cited by 441
Increased Osteoprotegerin Serum Levels in Men with Coronary Artery Disease
Schoppet, M., Sattler, A., Schaefer, J. R., Herzum, M., Maisch, B., & Hofbauer, L. C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020775 · Cited by 324
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Zaiss, M. M., Sarter, K., Hess, A., Engelke, K., Böhm, C., Nimmerjahn, F., Voll, R., Schett, G., & David, J. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27535 · Cited by 122
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight
Lee, S.-J., Lehar, A., Meir, J. U., Koch, C., Morgan, A., Warren, L. E., Rydzik, R., Youngstrom, D. W., Chandok, H., George, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014716117 · Cited by 115
Metadata
- Authors
- Zauli, G., Rimondi, E., Stea, S., Baruffaldi, F., Stebel, M., Zerbinati, C., Corallini, F., & Secchiero, P.
- Affiliations
- University of Trieste (IT)
- University of Ferrara (IT)
- Istituto Ortopedico Rizzoli (IT)
- Corresponding author
- Zauli, Giorgio
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2007-07-09
- Volume
- 214
- Issue
- 1
- Pages
- 117-125
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2127114138
- Cited by
- 63
- References
- 35
- Citations by year
- 2026: 1 · 2023: 1 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 8 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- TRAIL, osteoclastogenesis, RANKL, p27, ubiquitin-mediated proteolysis, osteoclast precursors, bone mass, trabecular thickness, traps, osteoprotegerin, TNF family ligands
- MeSH terms
- Tartrate-Resistant Acid Phosphatase, Acid Phosphatase, Animals, Cathepsins, Cell Differentiation, Cell Nucleus, Cell Separation, Cells, Cultured, Drug Administration Schedule, Enzyme-Linked Immunosorbent Assay, Fluorescent Dyes, Humans, Indoles, Injections, Subcutaneous, Isoenzymes, Leukocytes, Mononuclear, Osteoclasts, Recombinant Proteins, Solubility, Osteocalcin, RNA, Small Interfering, Cyclin-Dependent Kinase Inhibitor p27, Mice, TNF-Related Apoptosis-Inducing Ligand, RANK Ligand, Cathepsin K
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- CoChat. (2026). Citation check: TRAIL inhibits osteoclastic differentiation by counteracting RANKL‐dependent p27Kip1 accumulation in pre‐osteoclast precursors. https://app.cochat.ai/papers/10.1002/jcp.21165
- The paper
- Zauli, G., Rimondi, E., Stea, S., Baruffaldi, F., Stebel, M., Zerbinati, C., Corallini, F., & Secchiero, P. (2008). TRAIL inhibits osteoclastic differentiation by counteracting RANKL‐dependent p27Kip1 accumulation in pre‐osteoclast precursors. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.21165
