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Cross‐regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens
Open accessAbstract
Natural killer T (NKT) cells generally recognize lipid‐antigens presented in the context of the MHC class I‐like molecule CD1d. CD1d‐restricted NKT cells consist of two broad subsets: Type I, which express an invariant T cell receptor (TCR) and type II, which utilize diverse TCR gene segments. A major type II NKT subset has been shown to recognize a self‐glycolipid, sulfatide. Both subsets play important roles in autoimmune diseases, tumor surveillance, and infectious diseases. While type I NKT cells protect from tumor growth by enhancing tumor surveillance, type II NKT cells may suppress anti‐tumor immune responses. In a murine autoimmune hepatitis model, type I NKT cells contribute to pathogenesis, whereas activation of sulfatide‐reactive type II NKT cells protects from disease. Sulfatide‐mediated activation of type II NKT cells results in modification of dendritic cells and induction of anergy in type I NKT cells. Elucidation of this novel pathway of cross‐regulation among NKT cell subsets will provide tools for intervention in autoimmune diseases and for designing strategies for effective anti‐tumor immunity. J. Cell. Physiol. 218: 246–250, 2009. © 2008 Wiley‐Liss, Inc.
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“Type I NKT cells which possess a CD1d-restricted TCR are more abundant in mice, comprising up to 50% of total intrahepatic lymphocytes.”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [52]
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“In contrast, type II NKT cells with a more diverse TCR repertoire predominate in humans(52).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [52]
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“Reciprocally, severity of ASH in humans positively correlates with neutrophil dysfunction; removal of LPS ex vivo partially restoring normal neutrophil function (52).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [52]
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The liver as a central "hub" of the immune system: pathophysiological implications
Ronca, V., Gerussi, A., Collins, P., Parente, A., Oo, Y. H., & Invernizzi, P. (2025) · Physiological Reviews · doi:10.1152/physrev.00004.2023 · Cited by 59
Metadata
- Authors
- Arrenberg, P., Halder, R., & Kumar, V.
- Affiliations
- Torrey Pines Institute For Molecular Studies (US)
- Corresponding author
- Kumar, Vipin
- ORCID
- Kumar, Vipin
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2008-09-22
- Volume
- 218
- Issue
- 2
- Pages
- 246-250
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC2653050
- OpenAlex
- W2053031731
- Cited by
- 81
- References
- 0
- Citations by year
- 2025: 3 · 2024: 6 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 11
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA100660)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 645/1-1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- NKT cells, invariant natural killer T cells, type II NKT cells, CD1d, sulfatide, lipid antigen recognition, T cell receptor, cross-regulation, autoimmune hepatitis, T cell anergy, tumor surveillance, antitumor immunity, autoimmune disease
- MeSH terms
- Animals, Antigens, Humans, Immunity, Neoplasms, Autoimmunity, T-Lymphocyte Subsets, Natural Killer T-Cells
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- Arrenberg, P., Halder, R., & Kumar, V. (2009). Cross‐regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.21597
