Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?
Abstract
Bisphosphonates are considered the most effective drugs for controlling adult and pediatric osteolytic diseases. Although they have been used successfully for many years, several side effects, such as osteonecrosis of the jaw, delayed dental eruption, atypical femoral fracture, and alterations to the bone growth system, have been described. After an overview of nitrogenous bisphosphonate, the purpose of this article is to describe their mechanisms of action and current applications, review the preclinical and clinical evidence of their side effects in the skeleton ("what we know"), and describe current recommendations for preventing and managing these effects ("what we can do"). Finally, promising future directions on how to limit the occurrence of these side effects will be presented.
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Bisphosphonates inhibit the stimulatory activity of osteoclasts on osteoblast differentiation, and as a consequence, patients on these drugs suffer from a blockade of de novo bone formation.
“biphosphonates inhibit the stimulatory activity of osteoclasts on osteoblast differentiation and, as a consequence, patients on these drugs suffer from a blockade of de novo bone formation [12,70]”
From Osteoclasts and Microgravity (2020) · cites this paper as [70]
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Smith, J. K. (2020) · Life · doi:10.3390/life10090207 · Cited by 52 · see citing works
- Authors
- Vargas‐Franco, J. W., Castaneda, B., Rédiní, F., Gómez, D. F., Heymann, D., & Lézot, F.
- Affiliations
- UMR‐1238, INSERM, Equipe 1 Faculté de Médecine de l'Université de Nantes Nantes France
- INSERM, UMR‐1138, Equipe 5 Centre de Recherche des Cordeliers Paris France
- Inserm (FR)
- Universidad de Antioquia (CO)
- Corresponding author
- Lézot, Frédéric
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2018-03-07
- Volume
- 233
- Issue
- 8
- Pages
- 5696-5715
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2782861663
- Cited by
- 64
- References
- 4
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 3
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- bisphosphonates, osteonecrosis of the jaw, atypical femoral fractures, bone growth disorders, osteolytic diseases, adverse drug reactions, mechanism of action
- MeSH terms
- Animals, Diphosphonates, Humans, Osteonecrosis, Skeleton, Bone Density Conservation Agents
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