Protective effects of plant‐derived natural products on renal complications
Open accessAbstract
Diabetic nephropathy is the leading cause of renal failure worldwide. This debilitating disorder has several underlying pathophysiologic mechanisms, and therefore a variety of pharmacologic agents have been developed to prevent or treat diabetic nephropathy; however, synthetic drugs may possess unfavorable side effects. In response to this, the global use of herbal‐based pharmacologic agents is increasing among diabetic patients. Numerous studies have reported therapeutic benefits of herbal‐based compounds against diabetes‐induced renal dysfunction. These agents can prevent renal dysfunction and improve renal function by blocking or suppressing deleterious pathways such as oxidative stress, inflammation, apoptosis, necrosis, and nitric oxide deprivation that lead to vascular injuries. In the current study, we have reviewed the beneficial properties of the most common herbal agents used in renal complications and diabetic nephropathy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Crocin has antioxidant and reno-protective mechanisms by declining IL-18, Nox-4, and p53 and improving diabetic nephropathy.
“The antioxidant and reno-protective mechanisms have been observed for the carotenoid molecule, crocin, by declining Interleukin-18 (IL-18), Nox-4, and p53 and improving diabetic nephropathy (Yaribeygi et al. 2018).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Yaribeygi et al. 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 168 · Cited by 46
Research works printed but not linked: 4
- AKh, L. (2014). Diabetic nephropathy‐ complications and treatment. International Journal of Nephrology and Renovascular Disease, 7, 361–381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kundu, J. K. , & Surh, Y. J. (2004). Molecular basis of chemoprevention by resveratrol: NF‐kappaB and AP‐1 as potential targets. Mutation Research/DNA Repair, 555(1‐2), 65–80. [DOI] [PubMed] [Google Scholar]
- MA, H.‐J , & WU, G.‐Z (2014). Molecular mechanisms in the pathogenesis of diabetic nephropathy. Progress in modern Biomedicine, 16, 050. [Google Scholar]
- Yaribeygi, H. , Butler, A. E. , Barreto, G. E. , & Sahebkar, A. (2018d). Antioxidative potential of antidiabetic agents: A possible protective mechanism against vascular complications in diabetic patients. Journal of Cellular Physiology. [DOI] [PubMed] [Google Scholar]
- Authors
- Yaribeygi, H., Simental‐Mendía, L. E., Butler, A. E., & Sahebkar, A.
- Affiliations
- Shahid Beheshti University (IR)
- Mexican Social Security Institute (MX)
- Diabetes Research Center Qatar Biomedical Research Institute Doha Qatar
- Mashhad University of Medical Sciences (IR)
- Corresponding author
- Yaribeygi, Habib
- Sahebkar, Amirhossein
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2018-12-07
- Volume
- 234
- Issue
- 8
- Pages
- 12161-12172
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC13484185
- OpenAlex
- W2904762647
- Cited by
- 46
- References
- 168
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 5
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Licence
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- diabetic nephropathy, plant-derived natural products, herbal medicine, renal dysfunction, oxidative stress, inflammation, apoptosis, nitric oxide, vascular injury, renal protection
- MeSH terms
- Animals, Biological Products, Humans, Kidney, Kidney Diseases, Protective Agents, Plant Preparations
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
