MicroRNA‐33b regulates hepatocellular carcinoma cell proliferation, apoptosis, and mobility via targeting Fli‐1‐mediated Notch1 pathway
Abstract
MicroRNAs (miRNAs) have been confirmed to play pivotal roles in hepatocellular carcinoma (HCC) carcinogenesis. However, the underlying function of microRNA-33b (miR-33b) in HCC remains unclear. Here, we found that miR-33b level was significantly reduced in both HCC tissues and tumor cell lines. Further, luciferase reporter assay and western blot analysis confirmed that Friend leukemia virus integration 1 (Fli-1) was a direct target of miR-33b. Overexpression of miR-33b dramatically suppressed HCC tumor cell proliferation and cell mobility, but facilitated tumor cell apoptosis in vitro. Besides, restoration of Fli-1 partially attenuated miR-33b-mediated inhibition of cell growth and metastasis via activating Notch1 signaling and its downstream effectors. Our findings demonstrate the important role of miR-33b/Fli-1 axis in HCC progression and provide novel therapeutic candidates for HCC clinical treatment.
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miR-33b-3p selection in prostate cancer might depend on the prostate cell type.
“Given that miR-33b-5p could be detected as a major mature form in other type of cancer tissues (29, 30), we deduced that miR-33b-3p selection in prostate cancer might depend on the prostate cell type.”
From miR-33b-3p Acts as a Tumor Suppressor by Targeting DOCK4 in Prostate Cancer (2021) · cites this paper as [30]
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miR-33b-3p Acts as a Tumor Suppressor by Targeting DOCK4 in Prostate Cancer
Mei, Y., Li, K., Zhang, Z., Li, M., Yang, H., Wang, H., Huang, X., Li, X., Shi, S., & Yang, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.740452 · Cited by 10 · see citing works
“Given that miR-33b-5p could be detected as a major mature form in other type of cancer tissues (29, 30), we deduced that miR-33b-3p selection in prostate cancer might depend on the prostate cell type.”
BackgroundSelf-citation
- Authors
- Wang, H., Lin, X., Liu, E., Jian, Z., & Ou, Y.
- Affiliations
- Guangdong Academy of Medical Sciences (CN)
- Corresponding author
- Wang, Huiling
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2020-04-02
- Volume
- 235
- Issue
- 10
- Pages
- 7635-7644
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W3015038717
- Cited by
- 18
- References
- 0
- Citations by year
- 2025: 2 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Scientific Foundation of Guangdong Province (A2019558)
- The Science and Technology special Project of Guangdong Provincial People's Hospital (2018bq09)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- hepatocellular carcinoma, FLI1, Notch1 signaling, cell proliferation, apoptosis, tumor progression, microRNA target regulation
- MeSH terms
- Cell Line, Cell Movement, Carcinoma, Hepatocellular, Humans, Liver, Microfilament Proteins, Signal Transduction, Trans-Activators, Gene Expression Regulation, Neoplastic, Apoptosis, Disease Progression, MicroRNAs, Cell Line, Tumor, Cell Proliferation, Receptor, Notch1, Carcinogenesis
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