The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Developmental Changes in Pharmacokinetics and Pharmacodynamics
Open accessAbstract
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In pediatrics, age is a continuum that can and does add variability in drug disposition and effect. This article addresses the many important factors that influence drug disposition and effect relative to age. What is known about the influence of maturation on the processes of drug absorption, distribution, metabolism, excretion, and drug receptor dynamics are outlined. Our state of understanding of many of these factors remains in flux, however, and only with additional study will we be able to better anticipate and model drug‐response relationships across the age continuum. Being able to continuously improve our care of the ill pediatric patient while simultaneously being able to accurately determine the utility of new drugs and chemical entities in this population requires our enhanced understanding of these disposition characteristics.
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Cites
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Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
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Self-citationThe ontogeny of drug metabolism enzymes and implications for adverse drug events
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Impact of Obesity on Drug Metabolism and Elimination in Adults and Children
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Self-citationDevelopmental changes and polymorphism in human alcohol dehydrogenase
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Developmental Pharmacokinetics in Pediatric Populations
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Cited by
Vinarov, Z., Abdallah, M., Agundez, J. A. G., Allegaert, K., Basit, A. W., Braeckmans, M., Ceulemans, J., Corsetti, M., Griffin, B. T., Grimm, M., et al. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105812 · Cited by 359
Self-citationLin, W., Chen, Y., Unadkat, J. D., Zhang, X., Wu, D., & Heimbach, T. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03274-2 · Cited by 137
Sun, Z., Zhao, N., Zhao, X., Wang, Z., Liu, Z., & Cui, Y. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106838 · Cited by 65
Smits, A., Annaert, P., Cavallaro, G., De Cock, P. A. J. G., de Wildt, S. N., Kindblom, J. M., Lagler, F. B., Moreno, C., Pokorna, P., Schreuder, M. F., et al. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14958 · Cited by 55
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Metadata
- Authors
- van den Anker, J., Reed, M. D., Allegaert, K., & Kearns, G. L.
- Venue
- The Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2018-09-24
- Volume
- 58
- Issue
- S10
- Pages
- S10-S25
- ISSN
- 0021-9754 (ISSN-L)
- 0091-2700
- 1552-4604
- OpenAlex
- W2893814358
- Cited by
- 389
- References
- 95
- FWCI
- 22.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van den Anker, J., Reed, M. D., Allegaert, K., & Kearns, G. L. (2018). Developmental Changes in Pharmacokinetics and Pharmacodynamics. The Journal of Clinical Pharmacology. https://doi.org/10.1002/jcph.1284
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
