Lipid modulation of skeletal muscle mass and function
Open accessAbstract
Loss of skeletal muscle mass is a characteristic feature of various pathologies including cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the processes underlying its pathogenesis are not fully understood and may involve multiple factors. Importantly, there is growing evidence which supports a role for fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass and function. In this review, we discuss evidence pertaining to those pathways which are involved in the reduction, increase and/or preservation of skeletal muscle mass by such lipids under various pathological conditions, and highlight studies investigating how these processes may be influenced by dietary supplementation as well as genetic and/or pharmacological intervention.
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These molecular changes interact with each other, leading to a vicious cycle that impairs the regeneration of muscle and blocks the recovery of physical function.
“These molecular changes interact with each other, leading to a vicious cycle that impairs the regeneration of muscle and blocks the recovery of physical function.[ 16 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [16]
Deposition of intracellular lipids leads to mitochondrial dysfunction and increased ROS production in muscle, disrupts muscle protein synthesis, impairs skeletal muscle function, and causes sarcopenia.
“Recently, great importance has been attached to the deposition of intracellular lipids, which leads to further mitochondrial dysfunction and increased ROS production in muscle, disrupts muscle protein synthesis, and impairs skeletal muscle function, causing the development of sarcopenia [82].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [82]
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References 121 · Cited by 247
- Authors
- Lipina, C., & Hundal, H. S.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- Hundal, Harinder S
- Venue
- Journal of Cachexia, Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2016-10-08
- Volume
- 8
- Issue
- 2
- Pages
- 190-201
- ISSN
- 2190-5991 (ISSN-L)
- 2190-6009
- PMC
- PMC5377414
- OpenAlex
- W2531724552
- Cited by
- 247
- References
- 121
- Citations by year
- 2026: 28 · 2025: 24 · 2024: 37 · 2023: 32 · 2022: 33 · 2021: 29 · 2020: 20 · 2019: 19 · 2018: 19 · 2017: 6
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion, cc-by)
- Funders
- Diabetes UK
- Biotechnology and Biological Sciences Research Council (BB/I007261/1, BB/N002342/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- skeletal muscle mass, muscle function, fatty acids, lipid intermediates, sarcopenia, cachexia, muscle atrophy, muscle hypertrophy, aging, obesity, diabetes mellitus, cancer, dietary supplementation, pharmacological interventions
- MeSH terms
- Animals, Body Composition, Humans, Muscle, Skeletal, Lipid Metabolism
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