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Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae

Almeida, João RM, Modig, Tobias, Petersson, Anneli, Hähn‐Hägerdal, Bärbel, Lidén, Gunnar, Gorwa‐Grauslund, Marie F·2007·Journal of Chemical Technology & Biotechnology

Abstract

During hydrolysis of lignocellulosic biomass, monomeric sugars and a broad range of inhibitory compounds are formed and released. These inhibitors, which can be organized around three main groups, furans, weak acids and phenolics, reduce ethanol yield and productivity by affecting the microorganism performance during the fermentation step. Among the microorganisms that have been evaluated for lignocellulosic hydrolysate ethanol fermentation, the yeast Saccharomyces cerevisiae appears to be the least sensitive. In order to overcome the effect of inhibitors, strategies that include improvement of natural tolerance of microorganism and use of fermentation control strategies have been developed. An overview of the origin, effects and mechanisms of action of known inhibitors on S. cerevisiae is given. Fermentation control strategies as well as metabolic, genetic and evolutionary engineering strategies to obtain S. cerevisiae strains with improved tolerance are discussed. Copyright © 2007 Society of Chemical Industry

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Metadata

Authors
Almeida, J. R., Modig, T., Petersson, A., Hähn‐Hägerdal, B., Lidén, G., & Gorwa‐Grauslund, M. F.
Venue
Journal of Chemical Technology & Biotechnology
Publisher
Wiley
Published
2007-04
Volume
82
Issue
4
Pages
340-349
ISSN
  • 0142-0356 (ISSN-L)
  • 0268-2575
  • 1097-4660
OpenAlex
W2107910846
Cited by
987
References
2
FWCI
19.89
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae. https://app.cochat.ai/papers/10.1002/jctb.1676
The paper
Almeida, J. R., Modig, T., Petersson, A., Hähn‐Hägerdal, B., Lidén, G., & Gorwa‐Grauslund, M. F. (2007). Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae. Journal of Chemical Technology & Biotechnology. https://doi.org/10.1002/jctb.1676

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