The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A mechanistic model for penicillin production
Abstract
A mechanistic model for the production of penicillin has been investigated. Contois kinetics of growth coupled with a substrate‐inhibition model for product formation has been used to predict data for batch‐fed fermentation on synthetic and corn steep liquor medium. With the incorporation of oxygen limitation on growth and product formation it has been possible to investigate the effects of feeding rate, initial sugar concentration and the volumetric mass transfer coefficient for oxygen (K L a). Various experimentally observed trends for penicillin fermentation have been predicted qualitatively. Different product formation models have been critically reviewed with respect to the production of secondary metabolites.
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Cites
Pirt, S. J., & Righelato, R. C. (1967) · Applied Microbiology · doi:10.1128/aem.15.6.1284-1290.1967 · Cited by 157
Cited by
A modular simulation package for fed-batch fermentation: penicillin production
Birol, G., Ündey, C., & Çinar, A. (2002) · Computers & Chemical Engineering · doi:10.1016/s0098-1354(02)00127-8 · Cited by 655
Growth of Filamentous Fungi in Submerged Culture: Problems and Possible Solutions
Gibbs, P. A., Seviour, R. J., & Schmid, F. (2000) · Critical Reviews in Biotechnology · doi:10.1080/07388550091144177 · Cited by 329
Hybrid modeling of penicillin fermentation process based on least square support vector machine
Wang, X., Chen, J., Liu, C., & Pan, F. (2010) · Chemical Engineering Research and Design · doi:10.1016/j.cherd.2009.08.010 · Cited by 69
Metadata
- Authors
- Bajpai, R. K., & Reuß, M.
- Venue
- Journal of Chemical Technology and Biotechnology
- Publisher
- Wiley
- Published
- 1980-01
- Volume
- 30
- Issue
- 1
- Pages
- 332-344
- ISSN
- 0142-0356 (ISSN-L)
- 1935-181X
- OpenAlex
- W2100933114
- Cited by
- 190
- References
- 1
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A mechanistic model for penicillin production. https://app.cochat.ai/papers/10.1002/jctb.503300140
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- Bajpai, R. K., & Reuß, M. (1980). A mechanistic model for penicillin production. Journal of Chemical Technology and Biotechnology. https://doi.org/10.1002/jctb.503300140
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
