The performance of first-trimester ultrasound in diagnosing fetal cleft palate: Meta-analysis and systematic review
Open accessAbstract
Objective: This system review and meta‐analysis was aim to evaluate the accuracy of prenatal ultrasound in diagnosing cleft palates (CPs) during first trimester. Data Source: We systematically searched the databases of PubMed, Embase, and Cochrane Library for the articles, which assessed the accuracy of CPs diagnosed by ultrasound during first trimester. Review Method: The characteristics of the included studies were recorded. The quality of included studies was assessed by QUADAS‐2. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the curve (AUC) were calculated using Meta‐Disc software version 1.4. The publication bias was assessed by Stata software version 12.0. Results: This meta‐analysis included 13 studies with 39 806 fetuses. The pooled sensitivity, specificity, PLR, NLR were 0.874, 0.999, 689.84, and 0.161, respectively. The DOR and AUC were 6651.3 and 0.9084, respectively. Conclusion: The overall detection rate was 0.874, which indicated high value of first trimester ultrasound in diagnosing CPs.
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The overall detection rate of cleft palates was as high as 0.874 during the first-trimester ultrasound scan.
“This was also highlighted by a recent meta-analysis, which showed that the overall detection rate of cleft palates was as high as 0.874 during the first-trimester ultrasound scan [42].”
From First-Trimester Ultrasound: A Comparative Review of Guidelines (2026) · cites this paper as [42]
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First-Trimester Ultrasound: A Comparative Review of Guidelines
Boureka, E., Tsakiridis, I., Michos, G., Liberis, A., Giouleka, S., Mamopoulos, A., Kalogiannidis, I., & Dagklis, T. (2026) · Diagnostics · doi:10.3390/diagnostics16111695
- Authors
- Yu, D., Zhang, N., Sun, H., & Liu, M.
- Affiliations
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Women and Children's Hospital (CN)
- Corresponding author
- Liu, Meixin
- Venue
- Journal of Clinical Ultrasound
- Publisher
- Wiley
- Published
- 2023-06-12
- Volume
- 51
- Issue
- 6
- Pages
- 1015-1023
- ISSN
- 0091-2751 (ISSN-L)
- 1097-0096
- OpenAlex
- W4380302885
- Cited by
- 5
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Ultrasound (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Cleft Lip and Palate Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- first-trimester ultrasound, prenatal diagnosis, diagnostic accuracy, sensitivity and specificity, fetal malformations
- MeSH terms
- Cleft Palate, Female, Fetus, Humans, Pregnancy, Pregnancy Trimester, First, Sensitivity and Specificity, Ultrasonography
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