The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The spermatogonial stem cell niche
Open accessAbstract
Spermatogonial stem cells (SSCs; A s spermatogonia) and their direct descendants (A pr and A al spermatogonia) are preferentially located in those areas of the seminiferous tubules that border on the interstitial tissue. Fewer of these cells are present in tubule areas directly bordering on another tubule. Therefore, the SSC niche is related to the presence of interstitial tissue. The somatic cells within the seminiferous tubules, the Sertoli cells, are able to produce growth factors that stimulate self‐renewal (GDNF, FGF2) and differentiation (activin A, BMP4, and SCF) of the SSCs. As Sertoli cells are everywhere on the basal membrane of the tubules, other factors coming from outside the tubules must determine, either directly or indirectly via Sertoli cells, whether in a particular area self‐renewal of SSCs will be preferred or differentiation in the form of A pr formation. Self‐renewal will be preferred in the stem cell niche and differentiation outside of the niche. Factors that could link the niche to the interstitial tissue are CSF1, produced by Leydig cells that stimulate stem cell proliferation and FSH, the concentration of which will be highest near blood vessels and that stimulates GDNF production by Sertoli cells. Microsc. Res. Tech., 2009. © 2009 Wiley‐Liss, Inc.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Fujimoto, H., Sangai, T., Ishii, G., Ikehara, A., Nagashima, T., Miyazaki, M., & Ochiai, A. (2009) · International Journal of Cancer · doi:10.1002/ijc.24378 · Cited by 263
Goriely, A., McVean, G. A. T., van Pelt, A. M. M., O'Rourke, A. W., Wall, S. A., de Rooij, D. G., & Wilkie, A. O. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500267102 · Cited by 146
Cited by
The Blood-Testis Barrier and Its Implications for Male Contraception
Cheng, C. Y., & Mruk, D. D. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.002790 · Cited by 927
The nature and dynamics of spermatogonial stem cells
de Rooij, D. G. (2017) · Development · doi:10.1242/dev.146571 · Cited by 313
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Metadata
- Authors
- De Rooij, D. G.
- Venue
- Microscopy Research and Technique
- Publisher
- Wiley
- Published
- 2009-03-04
- Volume
- 72
- Issue
- 8
- Pages
- 580-585
- ISSN
- 1059-910X (ISSN-L)
- 1097-0029
- OpenAlex
- W2107542456
- Cited by
- 201
- References
- 4
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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