The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.
Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: Background to spermatogenesis, spermatogonia, and spermatocytes
Open accessAbstract
Spermatogenesis, a study of germ cell development, is a long, orderly, and well‐defined process occurring in seminiferous tubules of the testis. It is a temporal event whereby undifferentiated spermatogonial germ cells evolve into maturing spermatozoa over a period of several weeks. Spermatogenesis is characterized by three specific functional phases: proliferation, meiosis, and differentiation, and it involves spermatogonia, spermatocytes, and spermatids. Germ cells at steps of development form various cellular associations or stages, with 6, 12, and 14 specific stages being identified in human, mouse, and rat, respectively. The stages evolve over time in a given area of the seminiferous tubule forming a cycle of the seminiferous epithelium that has a well‐defined duration for a given species. In this part, we discuss the proliferation and meiotic phase whereby spermatogonia undergo several mitotic divisions to form spermatocytes that undergo two meiotic divisions to form haploid spermatids. In the rat, spermatogonia can be subdivided into several classes: stem cells (A s), proliferating cells (A pr, A al), and differentiating cells (A 1–A 4, In, B). They are dependent on a specific microenvironment (niche) contributed by Sertoli, myoid, and Leydig cells for proper development. Spermatogonia possess several surface markers whereby they can be identified from each other. During meiosis, spermatocytes undergo chromosomal pairing, synapsis, and genetic exchange as well as transforming into haploid cells following meiosis. The meiotic cells form specific structural entities such as the synaptonemal complex and sex body. Many genes involved in spermatogonial renewal and the meiotic process have been identified and shown to be essential for this event. Microsc. Res. Tech., 2010. © 2009 Wiley‐Liss, Inc.
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Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis
Chen, Y., Zheng, Y., Gao, Y., Lin, Z., Yang, S., Wang, T., Wang, Q., Xie, N., Hua, R., Liu, M., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0074-y · Cited by 420
Goriely, A., & Wilkie, A. O. M. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.017 · Cited by 365
Molecular insights into transgenerational non-genetic inheritance of acquired behaviours
Bohacek, J., & Mansuy, I. M. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3964 · Cited by 318
Autophagy regulates spermatid differentiation via degradation of PDLIM1
Shang, Y., Wang, H., Jia, P., Zhao, H., Liu, C., Liu, W., Song, Z., Xu, Z., Yang, L., Wang, Y., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1192750 · Cited by 154
The functional anatomy of the human spermatozoon: relating ultrastructure and function
Mortimer, D. (2018) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gay040 · Cited by 63
Metadata
- Authors
- Hermo, L., Pelletier, R. ‐., Cyr, D. G., & Smith, C. E.
- Venue
- Microscopy Research and Technique
- Publisher
- Wiley
- Published
- 2009-11-25
- Volume
- 73
- Issue
- 4
- Pages
- 241-278
- ISSN
- 1059-910X (ISSN-L)
- 1097-0029
- OpenAlex
- W2123272922
- Cited by
- 422
- References
- 322
- FWCI
- 25.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hermo, L., Pelletier, R. ‐., Cyr, D. G., & Smith, C. E. (2010). Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: Background to spermatogenesis, spermatogonia, and spermatocytes. Microscopy Research and Technique. https://doi.org/10.1002/jemt.20783
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