Targeted inhibition of osteosarcoma tumor growth by bone marrow‐derived mesenchymal stem cells expressing cytosine deaminase/5‐fluorocytosine in tumor‐bearing mice

NguyenThai, Quynh‐Anh; Sharma, Neelesh; Luong, Do Huynh; Sodhi, Simrinder Singh; Kim, Jeong‐Hyun; Kim, Nameun; Oh, Sung‐Jong; Jeong, Dong Kee

doi:10.1002/jgm.2826

Targeted inhibition of osteosarcoma tumor growth by bone marrow‐derived mesenchymal stem cells expressing cytosine deaminase/5‐fluorocytosine in tumor‐bearing mice

Background Mesenchymal stem cells (MSCs) are considered as an attractive approach for gene or drug delivery in cancer therapy. In the present study, the ability of human bone marrow‐derived MSCs expressing the cytosine deaminase/5‐fluorocytosine prodrug (CD/5‐FC MSCs) to target the human osteosar…