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The role of MIP-1α in Inflammation and hematopoiesis
Abstract
Macrophage inflammatory protein 1α (MIP-1α) is a member of the C-C subfamily of chemokines, a large superfamily of low-molecular-weight, inducible proteins that exhibit a variety of proinflammatory activities in vitro including leukocyte Chemotaxis. MIP-1α is a particularly interesting chemokine, because in addition to its proinflammatory activities, it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo. Here, the biologic properties of MIP-1α are reviewed in light of recent data on mice homozygous for a disruption of the MIP-1α gene. The MIP-1α null mice have no overt abnormalities of peripheral blood or bone marrow cells, indicating that MIP-1α is not necessary for normal hematopoiesis. However, the MIP-1α null mice have a reduced inflammatory response to influenza virus and are resistant to coxsackievirus-induced myocarditis. These data demonstrate that MIP-1α is required for a normal inflammatory response to these viruses. Agents that inhibit the action of MIP-1α may therefore prove useful for controlling inflammation in these and other settings.
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Metadata
- Authors
- Cook, D. N.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-01-01
- Volume
- 59
- Issue
- 1
- Pages
- 61-66
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W1830630019
- Cited by
- 214
- References
- 0
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cook, D. N. (1996). The role of MIP-1α in Inflammation and hematopoiesis. Journal of Leukocyte Biology. https://doi.org/10.1002/jlb.59.1.61
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
