The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169
Abstract
The transport of iron by RAW264.7 macrophage cell lines transfected with either Nramp1Gly169 (resistant) or Nramp1Asp169 (susceptible) alleles was assessed. We found no difference between resistant and susceptible cells in the rate of Fe import or export when Fe transport was measured in intact cells. In contrast, the rate of Fe import by latex-bead phagosomes isolated from resistant cells was more than double the rate by latex-bead phagosomes from susceptible cells. Similarly, phagosomes isolated from resistant cells that had been pre-labeled with 55Fe-citrate before phagocytosis contained up to four times as much Fe as the corresponding phagosomes from susceptible cells. Phagocytosis of Mycobacterium avium was accompanied by an increase in the production of hydroxyl radicals by Nramp1Gly169-transfected macrophages but not by macrophages transfected with the susceptible allele. These results are consistent with the hypothesis that Nramp1 functions to transport Fe into the bacterium-containing phagosome where it serves as a catalyst for the Haber-Weiss reaction, which accounts for the increased capacity of these cells to limit mycobacterial growth. J. Leukoc. Biol. 66: 113–119; 1999.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, some data suggest that Nramp1 in fact pumps iron into the phagolysosome where it may boost ROS generation [121, 122].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [121]
Citations
Cites
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104
Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D., & Andrews, N. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1148 · Cited by 936
Vidal, S., Tremblay, M. L., Govoni, G., Gauthier, S., Sebastiani, G., Malo, D., Skamene, E., Olivier, M., Jothy, S., & Gros, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.655 · Cited by 603
Via, L. E., Deretic, D., Ulmer, R. J., Hibler, N. S., Huber, L. A., & Deretic, V. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13326 · Cited by 558
Gruenheid, S., Pinner, E., Desjardins, M., & Gros, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.717 · Cited by 428
Nramp defines a family of membrane proteins.
Cellier, M. F., Privé, G. G., Belouchi, A., Kwan, T., Rodrigues, V., Chia, W., & Gros, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10089 · Cited by 352
Supek, F., Supekova, L., Nelson, H., & Nelson, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5105 · Cited by 325
Hackam, D. J., Rotstein, O. D., Zhang, W.-J., Gruenheid, S., Gros, P., & Grinstein, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.351 · Cited by 202
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–113 of 113
Penetration of three transmembrane segments of Slc11a1 in lipid bilayers
Qi, H., Wang, Y., Chu, H., Wang, W., & Mao, Q. (2013) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2013.11.033 · Cited by 3
Pakasi, T. A., Melani, A., Bramantyo, A. A., Putera, I., Syahmar, I., Karyadi, E., & Sahiratmadja, E. (2012) · Medical Journal of Indonesia · doi:10.13181/mji.v21i3.501 · Cited by 3
Interactions ofS. entericawith phagocytic cells
McCollister, B. D., & Vázquez‐Torres, A. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525360.010 · Cited by 3
Modulation of Iron Availability at the Host-Pathogen Interface in Phagocytic Cells
Forbes, J., Lam-Yuk-Tseung, S., & Gros, P. (2006) · EcoSal Plus · doi:10.1128/ecosalplus.8.8.10 · Cited by 2
Putra, W. P. B. P. (2019) · International Journal of Innovative Approaches in Agricultural Research · doi:10.29329/ijiaar.2019.217.17 · Cited by 1
Superantigen Activation of Macrophages
Chapes, S. K., Wright, A. D., & Beharka, A. A. (2001) · Infectious agents and pathogenesis · doi:10.1007/0-306-46848-4_5 · Cited by 1
Molecular regulation of iron homeostasis and resistance to infection in alcoholics
Barry, J. P. (2002) · Frontiers in bioscience · doi:10.2741/potter · Cited by 1
Chlamydophila pneumoniae in Cardiovascular Diseases : Clinical and Experimental Studies
Edvinsson, M. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Macrophage Antimycobacterial Activity, Effects of Stress on
Boomershine, C. S., & Zwilling, B. S. (2007) · Elsevier eBooks · doi:10.1016/b978-012373947-6.00243-9
Self-citationPeters, L. C. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2009.tde-08072009-122546
The effects of quercetin on iron metabolism
Hoque, R. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)
貴重書紹介 アンドレアス・ヴェサリウス『人体の構造についての七つの書』--1543年,バーゼル,オポリヌス書店刊 (蔵書の玉手箱)
鈴木, 秀. (2000) · 図書の譜
Susceptibilité mendélienne aux maladies infectieuses chez l'homme : déficits en NEMO et NRAMP1
Hubeau, M. (2013) · theses.fr (ABES) · doi:10.70675/3a76475dz8fbdz46b9z8759z2e9f0feaa160
Metadata
- Authors
- Kuhn, D. E., Baker, B. D., Lafuse, W. P., & Zwilling, B. S.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Zwilling, Bruce S
- ORCID
- Lafuse, William P
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-07-01
- Volume
- 66
- Issue
- 1
- Pages
- 113-119
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2465826357
- Cited by
- 113
- References
- 24
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl059795-05, 5r01mh054966-04, 5r01ai042901-13)
- National Heart, Lung, and Blood Institute (HL-59795)
- National Institute of Mental Health (MH 54966)
- National Institute of Allergy and Infectious Diseases (AI-42901)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- NRAMP1, ferroportin, iron transport, phagosome, macrophages, RAW 264.7 macrophages, Mycobacterium avium, phagocytosis, hydroxyl radicals, Haber-Weiss reaction, iron imports, iron export
- MeSH terms
- Natural Resistance-associated Macrophage Protein 1, Animals, Aspartic Acid, Biological Transport, Carrier Proteins, Cations, Cell Line, Glycine, Iron, Macrophages, Male, Membrane Proteins, Metals, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Microspheres, Phagosomes, Subcellular Fractions, Transfection, Blotting, Western, Hydroxyl Radical, Cation Transport Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
