Synthesis and quality control of [18F]T807 for tau PET imaging
Abstract
The detailed synthesis and quality control of [(18) F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end-of-synthesis of over 4.4 TBq/µmole (120 Ci/µmole) and an average radiochemical yield of 32%. Compliance with all standard US Pharmacopeia Chapter <823> acceptance tests was observed.
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18F-T807 is the most advanced tau PET tracer in terms of its investigation in vivo, with studies completed in numerous tauopathies including AD and PSP.
“18F-T807 is the most advanced tau PET tracer in terms of its investigation in vivo, with studies completed in numerous tauopathies including AD and PSP”
From Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) · cites this paper as Holt et al., 2016
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References 9 · Cited by 28
- Authors
- Holt, D. P., Ravert, H. T., & Dannals, R. F.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Holt, Daniel P.
- Venue
- Journal of Labelled Compounds and Radiopharmaceuticals
- Publisher
- Wiley
- Published
- 2016-07-17
- Volume
- 59
- Issue
- 10
- Pages
- 411-415
- ISSN
- 0362-4803 (ISSN-L)
- 1099-1344
- OpenAlex
- W2500510182
- Cited by
- 28
- References
- 9
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 1
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Labelled Compounds and Radiopharmaceuticals (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Avid Radiopharmaceuticals
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Chemical Reactions and Isotopes
- Keywords
- tau PET imaging, radiochemical yield, specific activity
- MeSH terms
- Carbolines, Quality Control, Radiochemistry, tau Proteins, Positron-Emission Tomography, Chemistry Techniques, Synthetic
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