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Cited by 404Advanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and ApplicationsNMR spectroscopy and applications

Methodology of brain perfusion imaging

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Barbier, Emmanuel L., Lamalle, Laurent, Décorps, Michel·2001·Journal of Magnetic Resonance Imaging
DOI 10.1002/jmri.1073
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Abstract

Numerous techniques have been proposed in the last 15 years to measure various perfusion-related parameters in the brain. In particular, two approaches have proven extremely successful: injection of paramagnetic contrast agents for measuring cerebral blood volumes (CBV) and arterial spin labeling (ASL) for measuring cerebral blood flows (CBF). This review presents the methodology of the different magnetic resonance imaging (MRI) techniques in use for CBV and CBF measurements and briefly discusses their limitations and potentials.

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References 242 · Cited by 404

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  1. [2]2. Hahn EL. Spin echoes. Phys Rev 1950;80:580-594.
  2. [7]7. Le Bihan D. Diffusion NMR imaging. Mag Reson Quarterly 1991; 7:1-30.
  3. [29]29. Detre JA, Leigh JS, Williams DS, Koretsky AP. Perfusion imaging. Magn Reson Med 1992;23:37-45.
  4. [32]32. Duong TQ. In vivo MR measurements of regional arterial and venous blood volume fractions in intact rat brain. Magn Reson Med 2000;43:393-402.
  5. [51]51. Kiselev VG, Posse S. Analytical model of susceptibility-induced MR signal dephasing: effect of diffusion in a microvascular network. Magn Reson Med 1999;41:499-509.
  6. [55]55. Tropres I, Grimault S, Vaeth A, et al. Vessel size imaging. Magn Reson Med 2001;in press.
  7. [64]64. Wirestam R, Andersson L, Ostergaard L, et al. Assessment of regional cerebral blood flow by dynamic susceptibility contrast MRI using different deconvolution techniques. Magn Reson Med 2000;43:691-700.
  8. [65]65. Smith AM, Grandin CB, Duprez T, Mataigne F, Cosnard G. Whole brain quantitative CBF and CBV measurements using MRI bolus tracking: comparison of methodologies. Magn Reson Med 2000; 43:559-564.
  9. [66]66. Vonken EPA, Beekman FJ, Bakker CJG, Viergever MA. Maximum likelihood estimation of cerebral blood flow in dynamic susceptibility contrast MRI. Magn Reson Med 1999;41:343-350.
  10. [68]68. Bo ¨rnert P, Aldefeld B, Eggers H. Reversed spiral imaging for increased T2* contrast. In: Proceedings of the 8th Annual Meeting of ISMRM, Denver, 2000. p 303.
  11. [71]71. Hou L, Yang Y, Mattay VS, Frank JA, Duyn JH. Optimization of fast acquisition methods for whole-brain relative cerebral blood volume (rCBV) mapping with susceptibility contrast agents. J Magn Reson Imaging 1999;9:233-239.
  12. [72]72. Oesterle C, Strohschein R, Ko ¨hler M, Schnell M, Hennig J. Benefits and pitfalls of keyhole imaging, especially in first-pass perfusion studies. J Magn Reson Imaging 2000;11:312-323.
  13. [77]77. Østergaard L, Rabinov J, Rosen BR, Gyldensted C. Simultaneous blood flow, blood volume and blood brain barrier permeability mapping using Gd-based contrast agents. Proceedings of the 4 th Annual Meeting of ISMRM, New York, 1996. p 1307.
  14. [78]78. Barbier EL, den Boer JA, Peters AR, Rozeboom AR, Sau J, Bonmartin A. A model of the dual effect of gadopentetate dimeglumine on dynamic brain MR images. J Magn Reson Imaging 1999; 10:242-253.
  15. [79]79. Haselhorst R, Kappos L, Bilecen D, et al. Dynamic susceptibility contrast MR imaging of plaque development in multiple sclerosis: application of an extended blood-brain barrier leakage correction. J Magn Reson Imaging 2000;11:495-505.
  16. [86]86. McKenzie CA, Pereira RS, Prato FS, Chen Z, Drost DJ. Improved contrast agent bolus tracking using T1 FARM. Magn Reson Med 1999;41:429-435.
  17. [105]105. Lin W, Celik A, Paczynski RP. Regional cerebral blood volume: a comparison of the dynamic imaging and the steady state methods. J Magn Reson Imaging 1999;9:44-52.
  18. [110]110. Speck O, Chang L, Itti L, Itti E, Ernst T. Comparison of static and dynamic MRI techniques for the measurement of regional cerebral blood volume. Magn Reson Med 1999;41:1264-1268.
  19. [113]113. Payen J-F, Briot E, Tropres I, Julien-Dolbec C, Montigon O, De ´corps M. Regional cerebral blood volume response to hypocapnia using susceptibility contrast MRI. NMR Biomed 2000;13:384391.
  20. [114]114. Scheffler K, Seifritz E, Haselhorst R, Bilecen D. Titration of the BOLD effect: separation and quantitation of blood volume and oxygenation changes in the human cerebral cortex during neuronal activation and ferumoxide infusion. Magn Reson Med 1999; 42:829-836.
  21. [116]116. Le Duc G, Pe ´oc'h M, Remy C, et al. Use of T2-weighted susceptibility contrast MRI for mapping the blood volume in the gliomabearing rat brain. Magn Reson Med 1999;42:754-761.
  22. [117]117. Simonsen CZ, Ostergaard L, Vestergaard-Poulsen P, Rohl L, Bjornerud A, Gyldensted C. CBF and CBV measurements by USPIO bolus tracking: reproducibility and comparison with Gd-based values. J Magn Reson Imaging 1999;9:342-347.
  23. [123]123. Kanno I, Uemura K, Miura S, Miura Y. HEADTOME: a hybrid emission tomograph for single photon and positron emission imaging of the brain. J Comput Assist Tomogr 1981;5:216-226.
  24. [162]162. Maccotta L, Detre JA, Alsop DC. The efficiency of adiabatic inversion for perfusion imaging by arterial spin labeling. NMR Biomed 1997;10:216-221.
  25. [163]163. Marro KI, Hayes CE, Kushmerick MJ. A model of the inversion process in an arterial inversion experiment. NMR Biomed 1997; 10:324-332.
  26. [171]171. Zaharchuk G, Ledden PJ, Kwong KK, Reese TG, Rosen BR, Wald LL. Multislice perfusion and perfusion territory imaging in humans with separate label and image coils. Magn Reson Med 1999; 41:1093-1098.
  27. [172]172. Lei H, Peeling J. A strategy to optimize the signal-to-noise ratio in one-coil arterial spin tagging perfusion imaging. Magn Reson Med 1999;41:563-568.
  28. [184]184. Mai VM, Berr SS. MR perfusion imaging of pulmonary parenchyma using pulsed arterial spin labeling techniques: FAIRER and FAIR. J Magn Reson Imaging 1999;9:483-487.
  29. [187]187. Chen Q, Siewert B, Bly BM, Warach S, Edelman RR. STARHASTE: perfusion imaging without magnetic susceptibility artifact. Magn Reson Med 1997;38:404-408.
  30. [189]189. Golay X, Stuber M, Pruessmann KP, Meier D, Boesiger P. Transfer insensitive labeling technique (TILT): application to multislice functional perfusion imaging. J Magn Reson Imaging 1999;9: 454-461.
  31. [190]190. Wong EC, Buxton RB, Frank LR. Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. NMR Biomed 1997;10:237-249.
  32. [25]25. racy of quantitative perfusion imaging using pulsed arterial spin labeling. Magn Reson Med 1999;41:1246-1254.
  33. [193]193. Calamante F, Williams SR, van Bruggen N, Kwong KK, Turner R. A model for quantification of perfusion in pulsed labeling techniques. NMR Biomed 1996;9:79-83.
  34. [197]197. Ye FQ, Frank JA, Weinberger DR, McLaughlin AC. Noise reduction in 3D perfusion imaging by attenuating the static signal in arterial spin tagging (ASSIST). Magn Reson Med 2000;44:92-100.
  35. [199]199. Barbier EL, Silva AC, Kim HJ, Williams DS, Koretsky AP. Perfusion analysis using dynamic arterial spin labeling (DASL). Magn Reson Med 1999;41:299-308.
  36. [200]200. Barbier EL, Silva AC, Kim S-G, Sau J, Mallet J-J, Koretsky AP. Simultaneous measurement of perfusion and vascular blood fraction using dynamic arterial spin labeling (DASL). In: Proceedings of the 7th Annual Meeting of ISMRM, Philadelphia, 1999. p 1744.
  37. [201]201. Blamire AM, Styles P. Spin echo entrapped perfusion image (SEEPAGE). A nonsubtraction method for direct imaging of perfusion. Magn Reson Med 2000;43:701-704.
  38. [202]202. Duyn J, Tan CX, van der Veen JW, et al. Perfusion-weighted 'single-trial' fMRI. In: Proceedings of the 8th Annual Meeting of ISMRM, Denver, 2000. p 55.
  39. [204]204. St. Lawrence KS, Frank JA, McLaughlin AC. Effect of restricted water exchange on cerebral blood flow values calculated with arterial spin tagging: a theoretical investigation. Magn Reson Med 2000;44:440-449.
  40. [205]205. Ewing JR, Fenstermacher JD. The single-coil arterial spin-tagging experiment for estimating cerebral blood flow as viewed from the capillary. What is the effective T1 of the experiment? In: Proceedings of the 7th Annual Meeting of ISMRM, Philadelphia, 1999. p 1846.
  41. [208]208. Hendrich KS, Kochanek PM, Williams DS, Schiding JK, Marion DW, Ho C. Early perfusion after controlled cortical impact in rats: quantification by arterial spin-labeled MRI and the influence of spin-lattice relaxation time heterogeneity. Magn Reson Med 1999; 42:673-681.
  42. [211]211. Pell GS, Proctor E, Thomas DL, Busza AL, Ordidge RJ. Validation of the FAIR technique of perfusion quantification with hydrogen clearance. In: Proceedings of the 7th Annual Meeting of ISMRM, Philadelphia, 1999. p 599.
  43. [213]213. Hoehn M, Kruger K, Busch E, Franke C. Validation of arterial spin tagging perfusion using MR imaging: correlation with autoradiographic CBF data. In: Proceedings of the 7th Annual Meeting of ISMRM, Philadelphia, 1999. p 1843.
  44. [214]214. Ye FQ, Berman KF, Ellmore T, et al. H215O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans. Magn Reson Med 2000;in press.
  45. [217]217. Kerskens CM, Hoehn-Berlage M, Schmitz B, et al. Ultrafast perfusion-weighted MRI of functional brain activation in rats during forepaw stimulation: comparison with T2-weighted MRI. NMR Biomed 1996;9:20-23.
  46. [220]220. Luh WM, Wong EC, Bandettini PA, Ward BD, Hyde JS. Comparison of simultaneously measured perfusion and BOLD signal increases during brain activation with T1-based tissue identification. Magn Reson Med 2000;44:137-143.
  47. [224]224. Gonzalez-At JB, Alsop DC, Detre JA. Cerebral perfusion and arterial transit time changes during task activation determined with continuous arterial spin labeling. Magn Reson Med 2000;43:739746.
  48. [228]228. Hendrich KS, Kochanek PM, Melick JA, et al. Characterization of cerebral blood flow during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats. In: Proceedings of the 8th Annual Meeting of ISMRM, Denver, 2000. p 1277.
  49. [234]234. Calamante F, Lythgoe MF, Pell GS, et al. Early changes in water diffusion, perfusion, T1, and T2 during focal cerebral ischemia in the rat studied at 8.5 T. Magn Reson Med 1999;41:479-485.
  50. [236]236. Detre JA, Samuels OB, Alsop DC, Gonzalez-At JB, Kasner SE, Raps EC. Noninvasive magnetic resonance imaging evaluation of cerebral blood flow with acetazolamide challenge in patients with cerebrovascular stenosis. J Magn Reson Imaging 1999;10:870-875.
  51. [238]238. Alsop DC, Detre JA, Grossman M. Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging. Ann Neurol 2000;47:93-100.
  52. [241]241. Silva AC, Kim SG, Garwood M. Imaging blood flow in brain tumors using arterial spin labeling. Magn Reson Med 2000;44:169-173.

Authors
Barbier, E. L., Lamalle, L., & Décorps, M.
Affiliations
  • National Institutes of Health (US)
  • Inserm (FR)
Corresponding author
Décorps, Michel
ORCID
Venue
Journal of Magnetic Resonance Imaging
Publisher
Wiley
Published
2001-03-21
Volume
13
Issue
4
Pages
496-520
ISSN
  • 1053-1807 (ISSN-L)
  • 1522-2586
DOI
10.1002/jmri.1073
OpenAlex
W2107547469
Cited by
404
References
242
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 4 · 2021: 6 · 2020: 11 · 2019: 6 · 2018: 14 · 2017: 15 · 2016: 11 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 16
FWCI
3.85
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Magnetic Resonance Imaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • NINDS research program
  • Région Rhône-Alpes
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
Keywords
brain perfusion imaging, cerebral blood volume, cerebral blood flow, paramagnetic contrast agents, arterial spin labeling
MeSH terms
Animals, Cerebrovascular Circulation, Contrast Media, Humans, Magnetic Resonance Imaging, Models, Theoretical, Spin Labels

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