The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Brain atrophy progression measured from registered serial MRI: Validation and application to alzheimer's disease
Abstract
In this paper, we validate the brain boundary shift integral (BBSI) as a measure of brain atrophy and demonstrate its application in Alzheimer's disease (AD). Nineteen normal subjects and nine patients with AD underwent serial three‐dimensional MRI (6‐ to 30‐month scan intervals). Repeat studies were registered to the baseline studies. The accuracy of the BBSI was assessed by comparison with simulated atrophy and with segmentation; it was also tested for reproducibility, linearity, and its ability to discriminate patients with AD from healthy controls. The BBSI correlated closely with simulated volumes of atrophy (r = 1.000). The mean absolute difference between repeat measures was 1.51 ml or .13% of mean brain volume. Rates of atrophy from all 18 AD scan pairs were widely separated from those of all 31 control pairs. In matched subgroups, the mean (SD) annual rate of brain atrophy in nine controls was .24% (.32%), compared with 2.78% (.92%) in nine patients with AD. We conclude that the BBSI is a linear and highly reproducible measure of atrophy with potential uses in the early diagnosis and measurement of progression in Alzheimer's disease.
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease
Seab, J. P., Jagust, W. J., Wong, S. T. S., Roos, M. S., Reed, B. R., & Budinger, T. F. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910080210 · Cited by 364
Cited by
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
The clinical use of structural MRI in Alzheimer disease
Frisoni, G. B., Fox, N. C., Jack, C. R., Scheltens, P., & Thompson, P. M. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.215 · Cited by 2,113
Self-citationComparison of different MRI brain atrophy rate measures with clinical disease progression in AD
Jack, C. R., Shiung, M. M., Gunter, J. L., O’Brien, P. C., Weigand, S. D., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Cha, R. H., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000110315.26026.ef · Cited by 827
Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD
Fotenos, A. F., Snyder, A. Z., Girton, L. E., Morris, J. C., & Buckner, R. L. (2005) · Neurology · doi:10.1212/01.wnl.0000154530.72969.11 · Cited by 579
Nestor, S. M., Rupsingh, R., Borrie, M., Smith, M., Accomazzi, V., Wells, J. L., Fogarty, J., Bartha, R., & Initiative, T. A. D. N. (2008) · Brain · doi:10.1093/brain/awn146 · Cited by 543
Metadata
- Authors
- Fox, N. C., & Freeborough, P. A.
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 1997-11
- Volume
- 7
- Issue
- 6
- Pages
- 1069-1075
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W2009739635
- Cited by
- 325
- References
- 2
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fox, N. C., & Freeborough, P. A. (1997). Brain atrophy progression measured from registered serial MRI: Validation and application to alzheimer's disease. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.1880070620
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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