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Cited by 113Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesAdvanced MRI Techniques and Applications

MR spectroscopy: Predicting long-term neuropsychological outcome following pediatric TBI

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Babikian, Talin, Freier, M. Catherin, Ashwal, Stephen, Riggs, Matt L., Burley, Todd, Holshouser, Barbara A.·2006·Journal of Magnetic Resonance Imaging
DOI 10.1002/jmri.20696
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Abstract

Purpose: To identify useful acute indicators of long‐term neurocognitive outcome beyond clinical variables for children and adolescents treated for a traumatic brain injury (TBI). Materials and Methods: The efficacy of magnetic resonance spectroscopy (MRS) acquired 6 ± 4 days after TBI in 20 children/adolescents in predicting intellectual and neuropsychological functioning one to four years post injury was assessed. Short echo‐time single voxel MRS (SVS) from normal‐appearing brain was compared to intermediate echo‐time multivoxel MR spectroscopic imaging (MRSI) from normal‐appearing and visibly‐injured brain acquired through the level of the corpus callosum (CC). Results: N‐acetyl aspartate (NAA) was moderate to strongly correlated with cognitive scores. Mean NAA/creatine (Cre) from MRSI alone explained over 40% of the variance in cognitive scores and 18% of the variance above and beyond demographic and clinical variables alone. Mild to moderate associations were noted between SVS metabolites (glutamate/glutamine [Glx] and myoinositol [mI]) and cognitive scores, with no such associations apparent for choline (Cho) or Cre. Exploratory analyses revealed trends for regional neuroimaging data and specific cognitive abilities. Conclusion: Acute MR spectroscopy of the pediatric brain injury patient improves prognostic ability and may provide valuable information for early treatment and intervention planning. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.

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  • M1 alterations in glutamate and abnormal interactions between M1 GABA and glutamate have been shown in the acute and chronic phases of TBI and sport-related mTBI using magnetic resonance spectroscopy.

    “M1 alterations in glutamate (Babikian et al., 2006; Henry et al, 2010; Shutter et al., 2004) and abnormal interactions between M1 GABA and glutamate (Tremblay et al., 2014) have been shown in the acute and chronic phases of TBI and sport-related mTBI using magnetic resonance spectroscopy.”

    From Theta burst stimulation to characterize changes in brain plasticity following mild traumatic brain injury: A proof-of-principle study (2015) · cites this paper as Babikian et al., 2006

    The Abstract and Discussion (pages unspecified in our copy) describe MRS measurements of glutamate/glutamine (Glx) after pediatric TBI, with scans acquired about 6 days after injury. The measured regions were occipital gray matter and parieto-occipital white matter, not M1; this paper does not establish chronic-phase or sport-related mTBI findings. The GABA interaction is attributed to a different citation in the sentence. (LLM, conf=0.88)

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Authors
Babikian, T., Freier, M. C., Ashwal, S., Riggs, M. L., Burley, T., & Holshouser, B. A.
Affiliations
  • University of California, Los Angeles (US)
  • Loma Linda University (US)
  • Portland State University (US)
  • Loma Linda University Medical Center (US)
Corresponding author
Babikian, Talin
ORCID
Venue
Journal of Magnetic Resonance Imaging
Publisher
Wiley
Published
2006-08-29
Volume
24
Issue
4
Pages
801-811
ISSN
  • 1053-1807 (ISSN-L)
  • 1522-2586
DOI
10.1002/jmri.20696
OpenAlex
W2090969222
Cited by
113
References
0
Citations by year
2024: 4 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 9 · 2013: 6 · 2012: 12
FWCI
5.61
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Magnetic Resonance Imaging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
pediatric traumatic brain injury, magnetic resonance spectroscopy, N-acetylaspartate, NAA/creatine ratio, glutamate/glutamine, myo-inositol, choline, cognitive outcomes, prognostic factors, corpus callosum, children and adolescents
MeSH terms
Adolescent, Aspartic Acid, Brain Injuries, Child, Child, Preschool, Creatine, Female, Glutamine, Humans, Infant, Inositol, Male, Neuropsychological Tests, Magnetic Resonance Spectroscopy, Predictive Value of Tests, Linear Models, Glutamic Acid, Statistics, Nonparametric, Recovery of Function

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